Engineering plasmonic nanorod arrays for colon cancer marker detection

Stephanie L Dodson, Cuong Cao, Hamed Zaribafzadeh, Shuzhou Li, Qihua Xiong

Research output: Contribution to journalArticle

14 Citations (Scopus)
313 Downloads (Pure)

Abstract

Engineering plasmonic nanomaterials or nanostructures towards ultrasensitive biosensing for disease markers or pathogens is of high importance. Here we demonstrate a systematic approach to tailor effective plasmonic nanorod arrays by combining both comprehensive numerical discrete dipole approximations (DDA) simulation and transmission spectroscopy experiments. The results indicate that 200×50 nm nanorod arrays with 300×500 nm period provide the highest FOM of 2.4 and a sensitivity of 310 nm/RIU. Furthermore, we demonstrate the use of nanorod arrays for the detection of single nucleotide polymorphism in codon 12 of the K-ras gene that are frequently occurring in early stages of colon cancer, with a sensitivity down to 10 nM in the presence of 100-fold higher concentration of the homozygous genotypes. Our work shows significant potential of nanorod arrays towards point-of-care applications in diagnosis and clinical studies.
Original languageEnglish
Pages (from-to)472-477
Number of pages6
JournalBiosensors and Bioelectronics
Volume63
Early online date07 Aug 2014
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Plasmonics
  • nanorod array
  • localized surface plasmon resonance
  • biosensing
  • discrete dipole approximation
  • single nucleotide polymorphism

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