Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece

Sophie Coulter; Sreekanth Pentlavalli; Lalitkumar Vora; Emily Cross; Ke Peng; Kate  McAulay; Ralf Schweins; Ryan F. Donnelly; Helen O. McCarthy; Garry Laverty

doi:10.1002/adhm.202370100

Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece

Sophie Coulter, Sreekanth Pentlavalli, Lalitkumar Vora, Emily Cross, Ke Peng, Kate McAulay, Ralf Schweins, Ryan F. Donnelly, Helen O. McCarthy, Garry Laverty

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Graphical Abstract
HIV/AIDS Drugs

In article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of a short peptide sequence attached to the HIV/AIDS drug zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms a drug-releasing hydrogel implant in response to phosphatase enzymes present within the skin space. Clinically relevant concentrations of zidovudine were delivered to rat models for 35 days, outlining the promise of this platform to improve patient adherence to HIV/AIDS drugs.

Original language	English
Article number	2370100
Journal	Advanced Healthcare Materials
Volume	12
Issue number	18
DOIs	https://doi.org/10.1002/adhm.202370100
Publication status	Published - 17 Jul 2023

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Coulter, S., Pentlavalli, S., Vora, L., Cross, E., Peng, K., McAulay, K., Schweins, R., Donnelly, R. F., McCarthy, H. O., & Laverty, G. (2023). Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece. Advanced Healthcare Materials, 12(18), Article 2370100. https://doi.org/10.1002/adhm.202370100

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title = "Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece",

abstract = "Graphical AbstractHIV/AIDS DrugsIn article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of a short peptide sequence attached to the HIV/AIDS drug zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms a drug-releasing hydrogel implant in response to phosphatase enzymes present within the skin space. Clinically relevant concentrations of zidovudine were delivered to rat models for 35 days, outlining the promise of this platform to improve patient adherence to HIV/AIDS drugs.",

author = "Sophie Coulter and Sreekanth Pentlavalli and Lalitkumar Vora and Emily Cross and Ke Peng and Kate McAulay and Ralf Schweins and Donnelly, {Ryan F.} and McCarthy, {Helen O.} and Garry Laverty",

year = "2023",

month = jul,

day = "17",

doi = "10.1002/adhm.202370100",

language = "English",

volume = "12",

journal = "Advanced Healthcare Materials",

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Coulter, S, Pentlavalli, S, Vora, L, Cross, E, Peng, K, McAulay, K, Schweins, R, Donnelly, RF , McCarthy, HO & Laverty, G 2023, 'Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece', Advanced Healthcare Materials, vol. 12, no. 18, 2370100. https://doi.org/10.1002/adhm.202370100

Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece. / Coulter, Sophie; Pentlavalli, Sreekanth; Vora, Lalitkumar et al.
In: Advanced Healthcare Materials, Vol. 12, No. 18, 2370100, 17.07.2023.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece

AU - Coulter, Sophie

AU - Pentlavalli, Sreekanth

AU - Vora, Lalitkumar

AU - Cross, Emily

AU - Peng, Ke

AU - McAulay, Kate

AU - Schweins, Ralf

AU - Donnelly, Ryan F.

AU - McCarthy, Helen O.

AU - Laverty, Garry

PY - 2023/7/17

Y1 - 2023/7/17

N2 - Graphical AbstractHIV/AIDS DrugsIn article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of a short peptide sequence attached to the HIV/AIDS drug zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms a drug-releasing hydrogel implant in response to phosphatase enzymes present within the skin space. Clinically relevant concentrations of zidovudine were delivered to rat models for 35 days, outlining the promise of this platform to improve patient adherence to HIV/AIDS drugs.

AB - Graphical AbstractHIV/AIDS DrugsIn article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of a short peptide sequence attached to the HIV/AIDS drug zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms a drug-releasing hydrogel implant in response to phosphatase enzymes present within the skin space. Clinically relevant concentrations of zidovudine were delivered to rat models for 35 days, outlining the promise of this platform to improve patient adherence to HIV/AIDS drugs.

U2 - 10.1002/adhm.202370100

DO - 10.1002/adhm.202370100

M3 - Article

SN - 2192-2659

VL - 12

JO - Advanced Healthcare Materials

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ER -

Enzyme‐triggered l ‐ α / d ‐peptide hydrogels as a long‐acting injectable platform for systemic delivery of HIV/AIDS drugs(Adv. Healthcare Mater. 18/2023) Frontispiece

Abstract

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