Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium

Halei C Benefield; Gary R Zirpoli; Emma H Allott; Yue Shan; Amber N Hurson; Angela R Omilian; Thaer Khoury; Chi-Chen Hong; Andrew F Olshan; Traci N Bethea; Elisa V Bandera; Julie R Palmer; Christine B Ambrosone; Melissa A Troester

doi:10.1158/1055-9965.EPI-20-0556

Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium

Halei C Benefield, Gary R Zirpoli, Emma H Allott, Yue Shan, Amber N Hurson, Angela R Omilian, Thaer Khoury, Chi-Chen Hong, Andrew F Olshan, Traci N Bethea, Elisa V Bandera, Julie R Palmer, Christine B Ambrosone, Melissa A Troester

Patrick G Johnston Centre for Cancer Research

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Abstract

BACKGROUND: Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker immunohistochemical classification of intrinsic subtypes included small numbers of black women.

METHODS: Using centralized laboratory results for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), proliferation marker Ki-67, epidermal growth factor receptor (EGFR), and cytokeratin (CK)5/6, we estimated case-only and case-control odds ratios (ORs) for established breast cancer risk factors among cases (n=2,354) and controls (n =2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression.

RESULTS: Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (versus nulliparity), and age at first birth. In case-control analyses for intrinsic subtype, increased body mass index (BMI) and waist-to-hip (WHR) ratio were associated with increased risk of luminal A subtype, while older age at menarche and parity, regardless of breastfeeding, were associated with reduced risk. For basal-like cancers, parity without breastfeeding and increasing WHR were associated with increased risk, whereas breastfeeding and age ≥ 25 years at first birth were associated with reduced risk among parous women. Basal-like and ER-/HER2+ subtypes had earlier age-at-incidence distribution relative to luminal subtypes.

CONCLUSIONS: Breast cancer subtypes show distinct etiologic profiles in the AMBER consortium, a study of over 5,000 black women with centrally assessed tumor biospecimens.

IMPACT: Among black women, high WHR and parity without breastfeeding are emerging as important intervention points to reduce the incidence of basal-like breast cancer.

Original language	English
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Early online date	23 Oct 2020
DOIs	https://doi.org/10.1158/1055-9965.EPI-20-0556
Publication status	Early online date - 23 Oct 2020

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Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium
Copyright ©2020, American Association for Cancer Research. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
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Benefield, H. C., Zirpoli, G. R., Allott, E. H., Shan, Y., Hurson, A. N., Omilian, A. R., Khoury, T., Hong, C-C., Olshan, A. F., Bethea, T. N., Bandera, E. V., Palmer, J. R., Ambrosone, C. B., & Troester, M. A. (2020). Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. https://doi.org/10.1158/1055-9965.EPI-20-0556

Benefield, Halei C ; Zirpoli, Gary R ; Allott, Emma H ; Shan, Yue ; Hurson, Amber N ; Omilian, Angela R ; Khoury, Thaer ; Hong, Chi-Chen ; Olshan, Andrew F ; Bethea, Traci N ; Bandera, Elisa V ; Palmer, Julie R ; Ambrosone, Christine B ; Troester, Melissa A. / Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium. In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2020.

@article{62e355cf1f9f46df85020ef1aaab1009,

title = "Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium",

abstract = "BACKGROUND: Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker immunohistochemical classification of intrinsic subtypes included small numbers of black women.METHODS: Using centralized laboratory results for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), proliferation marker Ki-67, epidermal growth factor receptor (EGFR), and cytokeratin (CK)5/6, we estimated case-only and case-control odds ratios (ORs) for established breast cancer risk factors among cases (n=2,354) and controls (n =2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression.RESULTS: Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (versus nulliparity), and age at first birth. In case-control analyses for intrinsic subtype, increased body mass index (BMI) and waist-to-hip (WHR) ratio were associated with increased risk of luminal A subtype, while older age at menarche and parity, regardless of breastfeeding, were associated with reduced risk. For basal-like cancers, parity without breastfeeding and increasing WHR were associated with increased risk, whereas breastfeeding and age ≥ 25 years at first birth were associated with reduced risk among parous women. Basal-like and ER-/HER2+ subtypes had earlier age-at-incidence distribution relative to luminal subtypes.CONCLUSIONS: Breast cancer subtypes show distinct etiologic profiles in the AMBER consortium, a study of over 5,000 black women with centrally assessed tumor biospecimens.IMPACT: Among black women, high WHR and parity without breastfeeding are emerging as important intervention points to reduce the incidence of basal-like breast cancer.",

author = "Benefield, {Halei C} and Zirpoli, {Gary R} and Allott, {Emma H} and Yue Shan and Hurson, {Amber N} and Omilian, {Angela R} and Thaer Khoury and Chi-Chen Hong and Olshan, {Andrew F} and Bethea, {Traci N} and Bandera, {Elisa V} and Palmer, {Julie R} and Ambrosone, {Christine B} and Troester, {Melissa A}",

note = "Copyright {\textcopyright}2020, American Association for Cancer Research.",

year = "2020",

month = oct,

day = "23",

doi = "10.1158/1055-9965.EPI-20-0556",

language = "English",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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Benefield, HC, Zirpoli, GR, Allott, EH, Shan, Y, Hurson, AN, Omilian, AR, Khoury, T, Hong, C-C, Olshan, AF, Bethea, TN, Bandera, EV, Palmer, JR, Ambrosone, CB & Troester, MA 2020, 'Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. https://doi.org/10.1158/1055-9965.EPI-20-0556

Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium. / Benefield, Halei C; Zirpoli, Gary R; Allott, Emma H; Shan, Yue; Hurson, Amber N; Omilian, Angela R; Khoury, Thaer; Hong, Chi-Chen; Olshan, Andrew F; Bethea, Traci N; Bandera, Elisa V; Palmer, Julie R; Ambrosone, Christine B; Troester, Melissa A.

In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 23.10.2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium

AU - Benefield, Halei C

AU - Zirpoli, Gary R

AU - Allott, Emma H

AU - Shan, Yue

AU - Hurson, Amber N

AU - Omilian, Angela R

AU - Khoury, Thaer

AU - Hong, Chi-Chen

AU - Olshan, Andrew F

AU - Bethea, Traci N

AU - Bandera, Elisa V

AU - Palmer, Julie R

AU - Ambrosone, Christine B

AU - Troester, Melissa A

PY - 2020/10/23

Y1 - 2020/10/23

N2 - BACKGROUND: Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker immunohistochemical classification of intrinsic subtypes included small numbers of black women.METHODS: Using centralized laboratory results for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), proliferation marker Ki-67, epidermal growth factor receptor (EGFR), and cytokeratin (CK)5/6, we estimated case-only and case-control odds ratios (ORs) for established breast cancer risk factors among cases (n=2,354) and controls (n =2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression.RESULTS: Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (versus nulliparity), and age at first birth. In case-control analyses for intrinsic subtype, increased body mass index (BMI) and waist-to-hip (WHR) ratio were associated with increased risk of luminal A subtype, while older age at menarche and parity, regardless of breastfeeding, were associated with reduced risk. For basal-like cancers, parity without breastfeeding and increasing WHR were associated with increased risk, whereas breastfeeding and age ≥ 25 years at first birth were associated with reduced risk among parous women. Basal-like and ER-/HER2+ subtypes had earlier age-at-incidence distribution relative to luminal subtypes.CONCLUSIONS: Breast cancer subtypes show distinct etiologic profiles in the AMBER consortium, a study of over 5,000 black women with centrally assessed tumor biospecimens.IMPACT: Among black women, high WHR and parity without breastfeeding are emerging as important intervention points to reduce the incidence of basal-like breast cancer.

AB - BACKGROUND: Evidence suggests etiologic heterogeneity among breast cancer subtypes. Previous studies with six-marker immunohistochemical classification of intrinsic subtypes included small numbers of black women.METHODS: Using centralized laboratory results for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), proliferation marker Ki-67, epidermal growth factor receptor (EGFR), and cytokeratin (CK)5/6, we estimated case-only and case-control odds ratios (ORs) for established breast cancer risk factors among cases (n=2,354) and controls (n =2,932) in the African American Breast Cancer Epidemiology and Risk (AMBER) consortium. ORs were estimated by ER status and intrinsic subtype using adjusted logistic regression.RESULTS: Case-only analyses by ER status showed etiologic heterogeneity by age at menarche, parity (versus nulliparity), and age at first birth. In case-control analyses for intrinsic subtype, increased body mass index (BMI) and waist-to-hip (WHR) ratio were associated with increased risk of luminal A subtype, while older age at menarche and parity, regardless of breastfeeding, were associated with reduced risk. For basal-like cancers, parity without breastfeeding and increasing WHR were associated with increased risk, whereas breastfeeding and age ≥ 25 years at first birth were associated with reduced risk among parous women. Basal-like and ER-/HER2+ subtypes had earlier age-at-incidence distribution relative to luminal subtypes.CONCLUSIONS: Breast cancer subtypes show distinct etiologic profiles in the AMBER consortium, a study of over 5,000 black women with centrally assessed tumor biospecimens.IMPACT: Among black women, high WHR and parity without breastfeeding are emerging as important intervention points to reduce the incidence of basal-like breast cancer.

U2 - 10.1158/1055-9965.EPI-20-0556

DO - 10.1158/1055-9965.EPI-20-0556

M3 - Article

C2 - 33097496

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

SN - 1055-9965

ER -

Benefield HC, Zirpoli GR, Allott EH, Shan Y, Hurson AN, Omilian AR et al. Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2020 Oct 23. https://doi.org/10.1158/1055-9965.EPI-20-0556

Epidemiology of basal-like and luminal breast cancers among black women in the AMBER consortium

Abstract

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