Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel

Rania Mahafdeh; Colin McCoy

doi:10.5920/bjpharm.1135

Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel

Rania Mahafdeh, Colin McCoy^*

^*Corresponding author for this work

School of Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Abstract

Hospital-acquired infection is one of the major risks to patients and an economic burden on the healthcare system, and multidrug resistance is a serious complicating factor in providing effective treatment. Novel drug delivery systems for antimicrobial agents can act as a solution for infection. In this study, the authors demonstrate a biomaterial with antimicrobial properties through the incorporation of ciprofloxacin into p(HEMA: MMA) polymer. The main aim is to prevent bacterial adherence on these surfaces, presenting a valuable strategy for nosocomial infection control. The adherence percentage of both S. aureus and E. coli were significantly decreased, and eradication to the below limit of detection was demonstrated for 24 hr, contributing to decreasing biofilm formation.

Original language	English
Title of host publication	Special issue on proceedings of the 13th APS PharmSci International Conference, Belfast 2022
Editors	Hannah Batchelor
Publisher	University of Huddersfield Press
Number of pages	2
DOIs	https://doi.org/10.5920/bjpharm.1135
Publication status	Published - 04 Nov 2022

Publication series

Name	British Journal of Pharmacy
Number	2
Volume	7
ISSN (Electronic)	2058-8356

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10.5920/bjpharm.1135Licence: CC BY

Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel
Copyright 2022 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 366 KBLicence: CC BY

Dual mechanism drug-eluting hydrogels with potential synergistic antitumour and antibacterial properties
Mahafdeh, R. M. Q. (Author), McCoy, C. (Supervisor), Carson, L. (Supervisor) & Moore, J. (Supervisor), Dec 2023
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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title = "Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel",

abstract = "Hospital-acquired infection is one of the major risks to patients and an economic burden on the healthcare system, and multidrug resistance is a serious complicating factor in providing effective treatment. Novel drug delivery systems for antimicrobial agents can act as a solution for infection. In this study, the authors demonstrate a biomaterial with antimicrobial properties through the incorporation of ciprofloxacin into p(HEMA: MMA) polymer. The main aim is to prevent bacterial adherence on these surfaces, presenting a valuable strategy for nosocomial infection control. The adherence percentage of both S. aureus and E. coli were significantly decreased, and eradication to the below limit of detection was demonstrated for 24 hr, contributing to decreasing biofilm formation.",

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Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel. / Mahafdeh, Rania; McCoy, Colin.
Special issue on proceedings of the 13th APS PharmSci International Conference, Belfast 2022. ed. / Hannah Batchelor. University of Huddersfield Press, 2022. 1135 (British Journal of Pharmacy; Vol. 7, No. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Mahafdeh, Rania

AU - McCoy, Colin

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N2 - Hospital-acquired infection is one of the major risks to patients and an economic burden on the healthcare system, and multidrug resistance is a serious complicating factor in providing effective treatment. Novel drug delivery systems for antimicrobial agents can act as a solution for infection. In this study, the authors demonstrate a biomaterial with antimicrobial properties through the incorporation of ciprofloxacin into p(HEMA: MMA) polymer. The main aim is to prevent bacterial adherence on these surfaces, presenting a valuable strategy for nosocomial infection control. The adherence percentage of both S. aureus and E. coli were significantly decreased, and eradication to the below limit of detection was demonstrated for 24 hr, contributing to decreasing biofilm formation.

AB - Hospital-acquired infection is one of the major risks to patients and an economic burden on the healthcare system, and multidrug resistance is a serious complicating factor in providing effective treatment. Novel drug delivery systems for antimicrobial agents can act as a solution for infection. In this study, the authors demonstrate a biomaterial with antimicrobial properties through the incorporation of ciprofloxacin into p(HEMA: MMA) polymer. The main aim is to prevent bacterial adherence on these surfaces, presenting a valuable strategy for nosocomial infection control. The adherence percentage of both S. aureus and E. coli were significantly decreased, and eradication to the below limit of detection was demonstrated for 24 hr, contributing to decreasing biofilm formation.

U2 - 10.5920/bjpharm.1135

DO - 10.5920/bjpharm.1135

M3 - Conference contribution

T3 - British Journal of Pharmacy

BT - Special issue on proceedings of the 13th APS PharmSci International Conference, Belfast 2022

A2 - Batchelor, Hannah

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ER -

Eradication of E. coli and S. aureus by Ciprofloxacin-loaded hydrogel

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Student theses

Dual mechanism drug-eluting hydrogels with potential synergistic antitumour and antibacterial properties

Cite this