Escherichia coli and Enterococcus faecalis whole cells and metabolic by-products reduce bladder cell viability

Gregor Reid; Lydia Dafoe; Brian Niven; Miguel Valvano

doi:10.1016/S0964-8305(97)00060-7

Escherichia coli and Enterococcus faecalis whole cells and metabolic by-products reduce bladder cell viability

Gregor Reid^*, Lydia Dafoe, Brian Niven, Miguel Valvano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The present study showed that three isolates each of E. faecalis and E. coli and their metabolic by-products significantly reduced the viability of uroepithelial cells within 1-4 h in vitro. Strains of Lactobacillus, renowned for their potential ability to reduce the incidence of urinary tract infections (UTI), did not confer the same degree of viability loss on the bladder cells compared with the pathogens. These results corroborate with clinical findings that the presence of uropathogens has a detrimental effect on the bladder mucosa. By not treating bacteriuria, the organisms are likely to continue to damage the host, whether or not symptoms and signs exist. The biodegradation of host cells has serious implications for the patient.

Original language	English
Pages (from-to)	37-41
Number of pages	5
Journal	International Biodeterioration and Biodegradation
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/S0964-8305(97)00060-7
Publication status	Published - 01 Jul 1997
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Biomaterials
Waste Management and Disposal

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abstract = "The present study showed that three isolates each of E. faecalis and E. coli and their metabolic by-products significantly reduced the viability of uroepithelial cells within 1-4 h in vitro. Strains of Lactobacillus, renowned for their potential ability to reduce the incidence of urinary tract infections (UTI), did not confer the same degree of viability loss on the bladder cells compared with the pathogens. These results corroborate with clinical findings that the presence of uropathogens has a detrimental effect on the bladder mucosa. By not treating bacteriuria, the organisms are likely to continue to damage the host, whether or not symptoms and signs exist. The biodegradation of host cells has serious implications for the patient.",

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AU - Niven, Brian

AU - Valvano, Miguel

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Y1 - 1997/7/1

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AB - The present study showed that three isolates each of E. faecalis and E. coli and their metabolic by-products significantly reduced the viability of uroepithelial cells within 1-4 h in vitro. Strains of Lactobacillus, renowned for their potential ability to reduce the incidence of urinary tract infections (UTI), did not confer the same degree of viability loss on the bladder cells compared with the pathogens. These results corroborate with clinical findings that the presence of uropathogens has a detrimental effect on the bladder mucosa. By not treating bacteriuria, the organisms are likely to continue to damage the host, whether or not symptoms and signs exist. The biodegradation of host cells has serious implications for the patient.

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Escherichia coli and Enterococcus faecalis whole cells and metabolic by-products reduce bladder cell viability

Abstract

ASJC Scopus subject areas

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