Estimating the Prevalence of Muscle Wasting, Weakness and Sarcopenia in Haemodialysis Patients

Adrian Slee, Clare McKeaveney, Gary Adamson, Andrew Davenport, Ken Farrington, Denis Fouque, Kamyar Kalantar-Zadeh, John Mallett, A. Peter Maxwell, Robert Mullan, Helen Noble, Donal ODonoghue, Sam Porter, David Seres, Joanne Shields, Miles Witham, Joanne Reid

Research output: Contribution to journalArticle

Abstract

Objectives: Haemodialysis (HD) patients suffer from nutritional problems, which include muscle wasting, weakness, and cachexia, and are associated with poor clinical outcomes. The European Working Group for Sarcopenia in Older People (EWGSOP) and Foundations for the National Institute of Health (FNIH) have developed criteria for the assessment of sarcopenia, including the use of non-invasive techniques such as bioelectrical impedance assessment (BIA), anthropometry, and hand grip strength (HGS) dynamometry. This study investigated the prevalence of muscle wasting, weakness, and sarcopenia using the EWGSOP and FNIH criteria. Methods: BIA was performed in 24 females (f) and 63 males (m) in the post-dialysis period. Total skeletal muscle mass and appendicular skeletal muscle mass were estimated and index values (i.e., muscle mass divided by height2 [kg/m2]) were calculated (Total Skeletal Muscle Index (TSMI) and Appendicular Skeletal Muscle Index (ASMI)). Mid-arm circumference and triceps skin-fold thickness were measured and mid-upper arm muscle circumference (MUAMC) calculated. HGS was measured using a standard protocol and Jamar dynamometer. Suggested cut-points for low muscle mass and grip strength were utilized using the EWGSOP and FNIH criteria with prevalence estimated, including sarcopenia. Results: The prevalence varied depending on methodology: low TSMI (moderate and severe sarcopenia combined) was 55% for whole group: 21% (f) and 68% (m). Low ASMI was 32% for whole group: 25% (f) and 35% (m). Low MUAMC was 25% for whole group: 0% (f) and 30% (m). ASMI highly correlated with Body Mass Index (r = 0.78, P < .001) and MUAMC (r = 0.68, P < .001). Muscle weakness was high regardless of cut-points used (50-71% (f); 60-79% (m)). Conclusions: Internationally, this is the first study comparing measures of muscle mass (TSMM and ASMM by BIA and MUAMC) and muscle strength (HGS) using this specific methodology in a haemodialysis population. Future work is required to confirm findings.
Original languageEnglish
JournalJournal of Renal Nutrition
Early online date14 Nov 2019
DOIs
Publication statusEarly online date - 14 Nov 2019

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Sarcopenia
Muscle Weakness
Hand Strength
Renal Dialysis
Skeletal Muscle
Muscles
Arm
National Institutes of Health (U.S.)
Electric Impedance
Anthropometry
Cachexia
Muscle Strength
Dialysis
Body Mass Index
Cross-Sectional Studies
Skin

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Slee, Adrian ; McKeaveney, Clare ; Adamson, Gary ; Davenport, Andrew ; Farrington, Ken ; Fouque, Denis ; Kalantar-Zadeh, Kamyar ; Mallett, John ; Maxwell, A. Peter ; Mullan, Robert ; Noble, Helen ; ODonoghue, Donal ; Porter, Sam ; Seres, David ; Shields, Joanne ; Witham, Miles ; Reid, Joanne. / Estimating the Prevalence of Muscle Wasting, Weakness and Sarcopenia in Haemodialysis Patients. In: Journal of Renal Nutrition. 2019.
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title = "Estimating the Prevalence of Muscle Wasting, Weakness and Sarcopenia in Haemodialysis Patients",
abstract = "Objectives: Haemodialysis (HD) patients suffer from nutritional problems, which include muscle wasting, weakness, and cachexia, and are associated with poor clinical outcomes. The European Working Group for Sarcopenia in Older People (EWGSOP) and Foundations for the National Institute of Health (FNIH) have developed criteria for the assessment of sarcopenia, including the use of non-invasive techniques such as bioelectrical impedance assessment (BIA), anthropometry, and hand grip strength (HGS) dynamometry. This study investigated the prevalence of muscle wasting, weakness, and sarcopenia using the EWGSOP and FNIH criteria. Methods: BIA was performed in 24 females (f) and 63 males (m) in the post-dialysis period. Total skeletal muscle mass and appendicular skeletal muscle mass were estimated and index values (i.e., muscle mass divided by height2 [kg/m2]) were calculated (Total Skeletal Muscle Index (TSMI) and Appendicular Skeletal Muscle Index (ASMI)). Mid-arm circumference and triceps skin-fold thickness were measured and mid-upper arm muscle circumference (MUAMC) calculated. HGS was measured using a standard protocol and Jamar dynamometer. Suggested cut-points for low muscle mass and grip strength were utilized using the EWGSOP and FNIH criteria with prevalence estimated, including sarcopenia. Results: The prevalence varied depending on methodology: low TSMI (moderate and severe sarcopenia combined) was 55{\%} for whole group: 21{\%} (f) and 68{\%} (m). Low ASMI was 32{\%} for whole group: 25{\%} (f) and 35{\%} (m). Low MUAMC was 25{\%} for whole group: 0{\%} (f) and 30{\%} (m). ASMI highly correlated with Body Mass Index (r = 0.78, P < .001) and MUAMC (r = 0.68, P < .001). Muscle weakness was high regardless of cut-points used (50-71{\%} (f); 60-79{\%} (m)). Conclusions: Internationally, this is the first study comparing measures of muscle mass (TSMM and ASMM by BIA and MUAMC) and muscle strength (HGS) using this specific methodology in a haemodialysis population. Future work is required to confirm findings.",
author = "Adrian Slee and Clare McKeaveney and Gary Adamson and Andrew Davenport and Ken Farrington and Denis Fouque and Kamyar Kalantar-Zadeh and John Mallett and Maxwell, {A. Peter} and Robert Mullan and Helen Noble and Donal ODonoghue and Sam Porter and David Seres and Joanne Shields and Miles Witham and Joanne Reid",
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Slee, A, McKeaveney, C, Adamson, G, Davenport, A, Farrington, K, Fouque, D, Kalantar-Zadeh, K, Mallett, J, Maxwell, AP, Mullan, R, Noble, H, ODonoghue, D, Porter, S, Seres, D, Shields, J, Witham, M & Reid, J 2019, 'Estimating the Prevalence of Muscle Wasting, Weakness and Sarcopenia in Haemodialysis Patients', Journal of Renal Nutrition. https://doi.org/10.1053/j.jrn.2019.09.004

Estimating the Prevalence of Muscle Wasting, Weakness and Sarcopenia in Haemodialysis Patients. / Slee, Adrian; McKeaveney, Clare; Adamson, Gary ; Davenport, Andrew; Farrington, Ken; Fouque, Denis; Kalantar-Zadeh, Kamyar; Mallett, John; Maxwell, A. Peter; Mullan, Robert; Noble, Helen; ODonoghue, Donal; Porter, Sam; Seres, David; Shields, Joanne; Witham, Miles; Reid, Joanne.

In: Journal of Renal Nutrition, 14.11.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Estimating the Prevalence of Muscle Wasting, Weakness and Sarcopenia in Haemodialysis Patients

AU - Slee, Adrian

AU - McKeaveney, Clare

AU - Adamson, Gary

AU - Davenport, Andrew

AU - Farrington, Ken

AU - Fouque, Denis

AU - Kalantar-Zadeh, Kamyar

AU - Mallett, John

AU - Maxwell, A. Peter

AU - Mullan, Robert

AU - Noble, Helen

AU - ODonoghue, Donal

AU - Porter, Sam

AU - Seres, David

AU - Shields, Joanne

AU - Witham, Miles

AU - Reid, Joanne

PY - 2019/11/14

Y1 - 2019/11/14

N2 - Objectives: Haemodialysis (HD) patients suffer from nutritional problems, which include muscle wasting, weakness, and cachexia, and are associated with poor clinical outcomes. The European Working Group for Sarcopenia in Older People (EWGSOP) and Foundations for the National Institute of Health (FNIH) have developed criteria for the assessment of sarcopenia, including the use of non-invasive techniques such as bioelectrical impedance assessment (BIA), anthropometry, and hand grip strength (HGS) dynamometry. This study investigated the prevalence of muscle wasting, weakness, and sarcopenia using the EWGSOP and FNIH criteria. Methods: BIA was performed in 24 females (f) and 63 males (m) in the post-dialysis period. Total skeletal muscle mass and appendicular skeletal muscle mass were estimated and index values (i.e., muscle mass divided by height2 [kg/m2]) were calculated (Total Skeletal Muscle Index (TSMI) and Appendicular Skeletal Muscle Index (ASMI)). Mid-arm circumference and triceps skin-fold thickness were measured and mid-upper arm muscle circumference (MUAMC) calculated. HGS was measured using a standard protocol and Jamar dynamometer. Suggested cut-points for low muscle mass and grip strength were utilized using the EWGSOP and FNIH criteria with prevalence estimated, including sarcopenia. Results: The prevalence varied depending on methodology: low TSMI (moderate and severe sarcopenia combined) was 55% for whole group: 21% (f) and 68% (m). Low ASMI was 32% for whole group: 25% (f) and 35% (m). Low MUAMC was 25% for whole group: 0% (f) and 30% (m). ASMI highly correlated with Body Mass Index (r = 0.78, P < .001) and MUAMC (r = 0.68, P < .001). Muscle weakness was high regardless of cut-points used (50-71% (f); 60-79% (m)). Conclusions: Internationally, this is the first study comparing measures of muscle mass (TSMM and ASMM by BIA and MUAMC) and muscle strength (HGS) using this specific methodology in a haemodialysis population. Future work is required to confirm findings.

AB - Objectives: Haemodialysis (HD) patients suffer from nutritional problems, which include muscle wasting, weakness, and cachexia, and are associated with poor clinical outcomes. The European Working Group for Sarcopenia in Older People (EWGSOP) and Foundations for the National Institute of Health (FNIH) have developed criteria for the assessment of sarcopenia, including the use of non-invasive techniques such as bioelectrical impedance assessment (BIA), anthropometry, and hand grip strength (HGS) dynamometry. This study investigated the prevalence of muscle wasting, weakness, and sarcopenia using the EWGSOP and FNIH criteria. Methods: BIA was performed in 24 females (f) and 63 males (m) in the post-dialysis period. Total skeletal muscle mass and appendicular skeletal muscle mass were estimated and index values (i.e., muscle mass divided by height2 [kg/m2]) were calculated (Total Skeletal Muscle Index (TSMI) and Appendicular Skeletal Muscle Index (ASMI)). Mid-arm circumference and triceps skin-fold thickness were measured and mid-upper arm muscle circumference (MUAMC) calculated. HGS was measured using a standard protocol and Jamar dynamometer. Suggested cut-points for low muscle mass and grip strength were utilized using the EWGSOP and FNIH criteria with prevalence estimated, including sarcopenia. Results: The prevalence varied depending on methodology: low TSMI (moderate and severe sarcopenia combined) was 55% for whole group: 21% (f) and 68% (m). Low ASMI was 32% for whole group: 25% (f) and 35% (m). Low MUAMC was 25% for whole group: 0% (f) and 30% (m). ASMI highly correlated with Body Mass Index (r = 0.78, P < .001) and MUAMC (r = 0.68, P < .001). Muscle weakness was high regardless of cut-points used (50-71% (f); 60-79% (m)). Conclusions: Internationally, this is the first study comparing measures of muscle mass (TSMM and ASMM by BIA and MUAMC) and muscle strength (HGS) using this specific methodology in a haemodialysis population. Future work is required to confirm findings.

U2 - 10.1053/j.jrn.2019.09.004

DO - 10.1053/j.jrn.2019.09.004

M3 - Article

JO - Journal of Renal Nutrition

JF - Journal of Renal Nutrition

SN - 1051-2276

ER -