Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

R. Chingono; H. Mebrahtu; Z. Mupambireyi; V. Simms; H. A. Weiss; P. Ndlovu; F. Charasika; M. Tomlinson; L. D. Cluver; F. M. Cowan; L. Sherr

doi:10.1186/s12887-018-1201-0

Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

R. Chingono, H. Mebrahtu^*, Z. Mupambireyi, V. Simms, H. A. Weiss, P. Ndlovu, F. Charasika, M. Tomlinson, L. D. Cluver, F. M. Cowan, L. Sherr

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

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Abstract

Background: HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents.

Methods: The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0-24months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12months after enrolment. A comprehensive process evaluation was conducted.

Discussion: The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments.

Original language	English
Article number	222
Journal	BMC Pediatrics
Volume	18
DOIs	https://doi.org/10.1186/s12887-018-1201-0
Publication status	Published - 09 Jul 2018
Externally published	Yes

Bibliographical note

Funding Information:
Our recognition and gratitude go out to our various partners USAID-PEPFAR (funding organisation), the PEPFAR OVC Technical Working Group (technical support) and World Education Zimbabwe (implementing partner). MT is a lead investigator with the Centre of Excellence in Human Development, University Witwatersrand, South Africa, and is supported by the National Research Foundation, South Africa.

Publisher Copyright:
© 2018 The Author(s).

Keywords

Case management
Early childhood stimulation
HIV exposed infants
Internal savings and lending scheme
Zimbabwe

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Evaluating the effectiveness of a multicomponent intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.87 MBLicence: CC BY

Cite this

Chingono, R., Mebrahtu, H., Mupambireyi, Z., Simms, V., Weiss, H. A., Ndlovu, P., Charasika, F., Tomlinson, M., Cluver, L. D., Cowan, F. M., & Sherr, L. (2018). Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial. BMC Pediatrics, 18, Article 222. https://doi.org/10.1186/s12887-018-1201-0

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abstract = "Background: HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents.Methods: The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0-24months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12months after enrolment. A comprehensive process evaluation was conducted. Discussion: The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments.",

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note = "Funding Information: Our recognition and gratitude go out to our various partners USAID-PEPFAR (funding organisation), the PEPFAR OVC Technical Working Group (technical support) and World Education Zimbabwe (implementing partner). MT is a lead investigator with the Centre of Excellence in Human Development, University Witwatersrand, South Africa, and is supported by the National Research Foundation, South Africa. Publisher Copyright: {\textcopyright} 2018 The Author(s).",

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Chingono, R, Mebrahtu, H, Mupambireyi, Z, Simms, V, Weiss, HA, Ndlovu, P, Charasika, F, Tomlinson, M, Cluver, LD, Cowan, FM & Sherr, L 2018, 'Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial', BMC Pediatrics, vol. 18, 222. https://doi.org/10.1186/s12887-018-1201-0

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T1 - Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

AU - Chingono, R.

AU - Mebrahtu, H.

AU - Mupambireyi, Z.

AU - Simms, V.

AU - Weiss, H. A.

AU - Ndlovu, P.

AU - Charasika, F.

AU - Tomlinson, M.

AU - Cluver, L. D.

AU - Cowan, F. M.

AU - Sherr, L.

N1 - Funding Information: Our recognition and gratitude go out to our various partners USAID-PEPFAR (funding organisation), the PEPFAR OVC Technical Working Group (technical support) and World Education Zimbabwe (implementing partner). MT is a lead investigator with the Centre of Excellence in Human Development, University Witwatersrand, South Africa, and is supported by the National Research Foundation, South Africa. Publisher Copyright: © 2018 The Author(s).

PY - 2018/7/9

Y1 - 2018/7/9

N2 - Background: HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents.Methods: The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0-24months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12months after enrolment. A comprehensive process evaluation was conducted. Discussion: The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments.

AB - Background: HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans saving programme for HIV positive parents.Methods: The study was a cluster-randomized controlled trial in 30 clinic sites in two districts in Zimbabwe. Clinics were randomised in a 1:1 allocation ratio to the Child Health Intervention for Development Outcomes (CHIDO) intervention or Ministry of Health standard care. The CHIDO intervention comprises three elements: a group ECS parenting programme, an internal savings and lending scheme (ISALS) and case-management home visits by village health workers. The intervention was aimed at caregiver-child dyads (child aged 0-24months) where the infant was HIV exposed or infected. The primary outcomes were cognitive development (assessed by the Mullen Scales of Early Learning) and retention of the child in HIV care, at 12months after enrolment. A comprehensive process evaluation was conducted. Discussion: The results of this cluster-randomised trial will provide important information regarding the effects of multi-component interventions in mitigating developmental delays in HIV-exposed infants living in resource-limited environments.

KW - Case management

KW - Early childhood stimulation

KW - HIV exposed infants

KW - Internal savings and lending scheme

KW - Zimbabwe

U2 - 10.1186/s12887-018-1201-0

DO - 10.1186/s12887-018-1201-0

M3 - Article

C2 - 29986688

AN - SCOPUS:85049792459

SN - 1471-2431

VL - 18

JO - BMC Pediatrics

JF - BMC Pediatrics

M1 - 222

ER -

Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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