Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

A. Osorio; R.L. Milne; G. Pita; P. Peterlongo; T. Heikkinen; J. Simard; G. Chenevix-Trench; A.B. Spurdle; J. Beesley; X. Chen; S. Healey; S.L. Neuhausen; Y.C. Ding; F.J. Couch; X. Wang; N. Lindor; S. Manoukian; M. Barile; A. Viel; L. Tizzoni; C.I. Szabo; L. Foretova; M. Zikan; K. Claes; M.H. Greene; P. Mai; G. Rennert; F. Lejbkowicz; O. Barnett-Griness; I.L. Andrulis; H. Ozcelik; N. Weerasooriya; A.M. Gerdes; M. Thomassen; D.G. Cruger; M.A. Caligo; E. Friedman; B. Kaufman; Y. Laitman; S. Cohen; T. Kontorovich; R. Gershoni-Baruch; E. Dagan; H. Jernstrom; M.S. Askmalm; B. Arver; B. Malmer; S.M. Domchek; K.L. Nathanson; J. Brunet; T.R.Y. Cajal; D. Yannoukakos; U. Hamann; F.B.L. Hogervorst; S. Verhoef; E.B.G. Garcia; J.T. Wijnen; A. Van Den Ouweland; D.F. Easton; S. Peock; M. Cook; C.T. Oliver; D. Frost; C. Luccarini; D.G. Evans; F. Lalloo; R. Eeles; G. Pichert; J. Cook; S. Hodgson; Patrick Morrison; F. Douglas; A.K. Godwin; O.M. Sinilnikova; L. Barjhoux; D. Stoppa-Lyonnet; V. Moncoutier; S. Giraud; C. Cassini; L. Olivier-Faivre; F. Revillion; J.P. Peyrat; D. Muller; J.P. Fricker; H.T. Lynch; E.M. John; S. Buys; M. Daly; J.L. Hopper; M.B. Terry; A. Miron; Y. Yassin; D. Goldgar; C.F. Singer; D. Gschwantler-Kaulich; G. Pfeiler; A.C. Spiess; T.V. Hansen; O.T. Johannsson; T. Kirchhoff; K. Offit; K. Kosarin; M. Piedmonte; G.C. Rodriguez; K. Wakeley; J.F. Boggess; J. Basil; P.E. Schwartz; S.V. Blank; A.E. Toland; M. Montagna; C. Casella; E.N. Imyanitov; A. Allavena; R.K. Schmutzler; B. Versmold; C. Engel; A. Meindl; N. Ditsch; N. Arnold; D. Niederacher; H. Deissler; B. Fiebig; R. Varon-Mateeva; D. Schaefer; U.G. Froster; T. Caldes; M. De La Hoya; L. McGuffog; A.C. Antoniou; H. Nevanlinna; P. Radice; J. Benitez

doi:10.1038/sj.bjc.6605416

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

A. Osorio, R.L. Milne, G. Pita, P. Peterlongo, T. Heikkinen, J. Simard, G. Chenevix-Trench, A.B. Spurdle, J. Beesley, X. Chen, S. Healey, S.L. Neuhausen, Y.C. Ding, F.J. Couch, X. Wang, N. Lindor, S. Manoukian, M. Barile, A. Viel, L. TizzoniC.I. Szabo, L. Foretova, M. Zikan, K. Claes, M.H. Greene, P. Mai, G. Rennert, F. Lejbkowicz, O. Barnett-Griness, I.L. Andrulis, H. Ozcelik, N. Weerasooriya, A.M. Gerdes, M. Thomassen, D.G. Cruger, M.A. Caligo, E. Friedman, B. Kaufman, Y. Laitman, S. Cohen, T. Kontorovich, R. Gershoni-Baruch, E. Dagan, H. Jernstrom, M.S. Askmalm, B. Arver, B. Malmer, S.M. Domchek, K.L. Nathanson, J. Brunet, T.R.Y. Cajal, D. Yannoukakos, U. Hamann, F.B.L. Hogervorst, S. Verhoef, E.B.G. Garcia, J.T. Wijnen, A. Van Den Ouweland, D.F. Easton, S. Peock, M. Cook, C.T. Oliver, D. Frost, C. Luccarini, D.G. Evans, F. Lalloo, R. Eeles, G. Pichert, J. Cook, S. Hodgson, Patrick Morrison, F. Douglas, A.K. Godwin, O.M. Sinilnikova, L. Barjhoux, D. Stoppa-Lyonnet, V. Moncoutier, S. Giraud, C. Cassini, L. Olivier-Faivre, F. Revillion, J.P. Peyrat, D. Muller, J.P. Fricker, H.T. Lynch, E.M. John, S. Buys, M. Daly, J.L. Hopper, M.B. Terry, A. Miron, Y. Yassin, D. Goldgar, C.F. Singer, D. Gschwantler-Kaulich, G. Pfeiler, A.C. Spiess, T.V. Hansen, O.T. Johannsson, T. Kirchhoff, K. Offit, K. Kosarin, M. Piedmonte, G.C. Rodriguez, K. Wakeley, J.F. Boggess, J. Basil, P.E. Schwartz, S.V. Blank, A.E. Toland, M. Montagna, C. Casella, E.N. Imyanitov, A. Allavena, R.K. Schmutzler, B. Versmold, C. Engel, A. Meindl, N. Ditsch, N. Arnold, D. Niederacher, H. Deissler, B. Fiebig, R. Varon-Mateeva, D. Schaefer, U.G. Froster, T. Caldes, M. De La Hoya, L. McGuffog, A.C. Antoniou, H. Nevanlinna, P. Radice, J. Benitez

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers.

Original language	English
Pages (from-to)	2048-2054
Number of pages	7
Journal	British Journal of Cancer
Volume	101
Issue number	12
DOIs	https://doi.org/10.1038/sj.bjc.6605416
Publication status	Published - Dec 2009

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605416

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Osorio, A., Milne, R. L., Pita, G., Peterlongo, P., Heikkinen, T., Simard, J., Chenevix-Trench, G., Spurdle, A. B., Beesley, J., Chen, X., Healey, S., Neuhausen, S. L., Ding, Y. C., Couch, F. J., Wang, X., Lindor, N., Manoukian, S., Barile, M., Viel, A., ... Benitez, J. (2009). Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). British Journal of Cancer, 101(12), 2048-2054. https://doi.org/10.1038/sj.bjc.6605416

@article{cbece16edad643bf9b1bc6a139d2a02f,

title = "Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)",

abstract = "BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers.",

author = "A. Osorio and R.L. Milne and G. Pita and P. Peterlongo and T. Heikkinen and J. Simard and G. Chenevix-Trench and A.B. Spurdle and J. Beesley and X. Chen and S. Healey and S.L. Neuhausen and Y.C. Ding and F.J. Couch and X. Wang and N. Lindor and S. Manoukian and M. Barile and A. Viel and L. Tizzoni and C.I. Szabo and L. Foretova and M. Zikan and K. Claes and M.H. Greene and P. Mai and G. Rennert and F. Lejbkowicz and O. Barnett-Griness and I.L. Andrulis and H. Ozcelik and N. Weerasooriya and A.M. Gerdes and M. Thomassen and D.G. Cruger and M.A. Caligo and E. Friedman and B. Kaufman and Y. Laitman and S. Cohen and T. Kontorovich and R. Gershoni-Baruch and E. Dagan and H. Jernstrom and M.S. Askmalm and B. Arver and B. Malmer and S.M. Domchek and K.L. Nathanson and J. Brunet and T.R.Y. Cajal and D. Yannoukakos and U. Hamann and F.B.L. Hogervorst and S. Verhoef and E.B.G. Garcia and J.T. Wijnen and {Van Den Ouweland}, A. and D.F. Easton and S. Peock and M. Cook and C.T. Oliver and D. Frost and C. Luccarini and D.G. Evans and F. Lalloo and R. Eeles and G. Pichert and J. Cook and S. Hodgson and Patrick Morrison and F. Douglas and A.K. Godwin and O.M. Sinilnikova and L. Barjhoux and D. Stoppa-Lyonnet and V. Moncoutier and S. Giraud and C. Cassini and L. Olivier-Faivre and F. Revillion and J.P. Peyrat and D. Muller and J.P. Fricker and H.T. Lynch and E.M. John and S. Buys and M. Daly and J.L. Hopper and M.B. Terry and A. Miron and Y. Yassin and D. Goldgar and C.F. Singer and D. Gschwantler-Kaulich and G. Pfeiler and A.C. Spiess and T.V. Hansen and O.T. Johannsson and T. Kirchhoff and K. Offit and K. Kosarin and M. Piedmonte and G.C. Rodriguez and K. Wakeley and J.F. Boggess and J. Basil and P.E. Schwartz and S.V. Blank and A.E. Toland and M. Montagna and C. Casella and E.N. Imyanitov and A. Allavena and R.K. Schmutzler and B. Versmold and C. Engel and A. Meindl and N. Ditsch and N. Arnold and D. Niederacher and H. Deissler and B. Fiebig and R. Varon-Mateeva and D. Schaefer and U.G. Froster and T. Caldes and {De La Hoya}, M. and L. McGuffog and A.C. Antoniou and H. Nevanlinna and P. Radice and J. Benitez",

year = "2009",

month = dec,

doi = "10.1038/sj.bjc.6605416",

language = "English",

volume = "101",

pages = "2048--2054",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "12",

}

Osorio, A, Milne, RL, Pita, G, Peterlongo, P, Heikkinen, T, Simard, J, Chenevix-Trench, G, Spurdle, AB, Beesley, J, Chen, X, Healey, S, Neuhausen, SL, Ding, YC, Couch, FJ, Wang, X, Lindor, N, Manoukian, S, Barile, M, Viel, A, Tizzoni, L, Szabo, CI, Foretova, L, Zikan, M, Claes, K, Greene, MH, Mai, P, Rennert, G, Lejbkowicz, F, Barnett-Griness, O, Andrulis, IL, Ozcelik, H, Weerasooriya, N, Gerdes, AM, Thomassen, M, Cruger, DG, Caligo, MA, Friedman, E, Kaufman, B, Laitman, Y, Cohen, S, Kontorovich, T, Gershoni-Baruch, R, Dagan, E, Jernstrom, H, Askmalm, MS, Arver, B, Malmer, B, Domchek, SM, Nathanson, KL, Brunet, J, Cajal, TRY, Yannoukakos, D, Hamann, U, Hogervorst, FBL, Verhoef, S, Garcia, EBG, Wijnen, JT, Van Den Ouweland, A, Easton, DF, Peock, S, Cook, M, Oliver, CT, Frost, D, Luccarini, C, Evans, DG, Lalloo, F, Eeles, R, Pichert, G, Cook, J, Hodgson, S, Morrison, P, Douglas, F, Godwin, AK, Sinilnikova, OM, Barjhoux, L, Stoppa-Lyonnet, D, Moncoutier, V, Giraud, S, Cassini, C, Olivier-Faivre, L, Revillion, F, Peyrat, JP, Muller, D, Fricker, JP, Lynch, HT, John, EM, Buys, S, Daly, M, Hopper, JL, Terry, MB, Miron, A, Yassin, Y, Goldgar, D, Singer, CF, Gschwantler-Kaulich, D, Pfeiler, G, Spiess, AC, Hansen, TV, Johannsson, OT, Kirchhoff, T, Offit, K, Kosarin, K, Piedmonte, M, Rodriguez, GC, Wakeley, K, Boggess, JF, Basil, J, Schwartz, PE, Blank, SV, Toland, AE, Montagna, M, Casella, C, Imyanitov, EN, Allavena, A, Schmutzler, RK, Versmold, B, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Niederacher, D, Deissler, H, Fiebig, B, Varon-Mateeva, R, Schaefer, D, Froster, UG, Caldes, T, De La Hoya, M, McGuffog, L, Antoniou, AC, Nevanlinna, H, Radice, P & Benitez, J 2009, 'Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)', British Journal of Cancer, vol. 101, no. 12, pp. 2048-2054. https://doi.org/10.1038/sj.bjc.6605416

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). / Osorio, A.; Milne, R.L.; Pita, G. et al.

In: British Journal of Cancer, Vol. 101, No. 12, 12.2009, p. 2048-2054.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

AU - Osorio, A.

AU - Milne, R.L.

AU - Pita, G.

AU - Peterlongo, P.

AU - Heikkinen, T.

AU - Simard, J.

AU - Chenevix-Trench, G.

AU - Spurdle, A.B.

AU - Beesley, J.

AU - Chen, X.

AU - Healey, S.

AU - Neuhausen, S.L.

AU - Ding, Y.C.

AU - Couch, F.J.

AU - Wang, X.

AU - Lindor, N.

AU - Manoukian, S.

AU - Barile, M.

AU - Viel, A.

AU - Tizzoni, L.

AU - Szabo, C.I.

AU - Foretova, L.

AU - Zikan, M.

AU - Claes, K.

AU - Greene, M.H.

AU - Mai, P.

AU - Rennert, G.

AU - Lejbkowicz, F.

AU - Barnett-Griness, O.

AU - Andrulis, I.L.

AU - Ozcelik, H.

AU - Weerasooriya, N.

AU - Gerdes, A.M.

AU - Thomassen, M.

AU - Cruger, D.G.

AU - Caligo, M.A.

AU - Friedman, E.

AU - Kaufman, B.

AU - Laitman, Y.

AU - Cohen, S.

AU - Kontorovich, T.

AU - Gershoni-Baruch, R.

AU - Dagan, E.

AU - Jernstrom, H.

AU - Askmalm, M.S.

AU - Arver, B.

AU - Malmer, B.

AU - Domchek, S.M.

AU - Nathanson, K.L.

AU - Brunet, J.

AU - Cajal, T.R.Y.

AU - Yannoukakos, D.

AU - Hamann, U.

AU - Hogervorst, F.B.L.

AU - Verhoef, S.

AU - Garcia, E.B.G.

AU - Wijnen, J.T.

AU - Van Den Ouweland, A.

AU - Easton, D.F.

AU - Peock, S.

AU - Cook, M.

AU - Oliver, C.T.

AU - Frost, D.

AU - Luccarini, C.

AU - Evans, D.G.

AU - Lalloo, F.

AU - Eeles, R.

AU - Pichert, G.

AU - Cook, J.

AU - Hodgson, S.

AU - Morrison, Patrick

AU - Douglas, F.

AU - Godwin, A.K.

AU - Sinilnikova, O.M.

AU - Barjhoux, L.

AU - Stoppa-Lyonnet, D.

AU - Moncoutier, V.

AU - Giraud, S.

AU - Cassini, C.

AU - Olivier-Faivre, L.

AU - Revillion, F.

AU - Peyrat, J.P.

AU - Muller, D.

AU - Fricker, J.P.

AU - Lynch, H.T.

AU - John, E.M.

AU - Buys, S.

AU - Daly, M.

AU - Hopper, J.L.

AU - Terry, M.B.

AU - Miron, A.

AU - Yassin, Y.

AU - Goldgar, D.

AU - Singer, C.F.

AU - Gschwantler-Kaulich, D.

AU - Pfeiler, G.

AU - Spiess, A.C.

AU - Hansen, T.V.

AU - Johannsson, O.T.

AU - Kirchhoff, T.

AU - Offit, K.

AU - Kosarin, K.

AU - Piedmonte, M.

AU - Rodriguez, G.C.

AU - Wakeley, K.

AU - Boggess, J.F.

AU - Basil, J.

AU - Schwartz, P.E.

AU - Blank, S.V.

AU - Toland, A.E.

AU - Montagna, M.

AU - Casella, C.

AU - Imyanitov, E.N.

AU - Allavena, A.

AU - Schmutzler, R.K.

AU - Versmold, B.

AU - Engel, C.

AU - Meindl, A.

AU - Ditsch, N.

AU - Arnold, N.

AU - Niederacher, D.

AU - Deissler, H.

AU - Fiebig, B.

AU - Varon-Mateeva, R.

AU - Schaefer, D.

AU - Froster, U.G.

AU - Caldes, T.

AU - De La Hoya, M.

AU - McGuffog, L.

AU - Antoniou, A.C.

AU - Nevanlinna, H.

AU - Radice, P.

AU - Benitez, J.

PY - 2009/12

Y1 - 2009/12

N2 - BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers.

AB - BACKGROUND: In this study we aimed to evaluate the role of a SNP in intron I of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast cancer risk modifier in BRCA1 and BRCA2 mutation carriers.

U2 - 10.1038/sj.bjc.6605416

DO - 10.1038/sj.bjc.6605416

M3 - Article

C2 - 19920816

VL - 101

SP - 2048

EP - 2054

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 12

ER -

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

Abstract

ASJC Scopus subject areas

UN SDGs

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