Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen

Rachel V McCarter, Gareth J McKay, Nicola B Quinn, Usha Chakravarthy, Tom J MacGillivray, Gavin Robertson, Enrico Pellegrini, Emanuele Trucco, Michelle C Williams, Tunde Peto, Baljean Dhillon, Edwin Jr van Beek, David E Newby, Frank Kee, Ian S Young, Ruth E Hogg

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Abstract

PURPOSE: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort.

METHODS: A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angiography (CTCA) underwent ultrawide field (UWF) retinal imaging CAD determined by CTCA and was categorised as normal, non-obstructive or obstructive. Specific AMD features in UWF images were graded. Standardised grids were used to record the spatial location of AMD features, including RPD. Multivariate confounder adjusted regression models assessed the association between RPD and CAD.

RESULTS: The 534 participants were aged 27-75 years (mean 58±9 years; 425 (80%) ≥50 years) with a male preponderance (56%). Within the study sample, 178 (33%) had no CAD, 351 (66%) had CAD. RPD was detected in 30 participants (5.6%) and bilaterally in 23. Most participants with bilateral RPD had intermediate AMD 17 (74%). After adjustment for potential confounders (age, sex, drusen >125 µm, smoking status), multivariate analysis found no significant association between CAD and RPD (OR 1.31; 95% CI (0.57 to 3.01); p=0.52). A significant association was identified between RPD and intermediate AMD (OR 3.18; 95% CI (1.61 to 6.27); p=0.001).

CONCLUSION: We found no evidence to support an association between CAD and RPD. RPD was strongly associated with intermediate AMD features.

TRIAL REGISTRATION NUMBER: NCT01149590, Post results.

Original languageEnglish
Pages (from-to)1-7
JournalBritish Journal of Ophthalmology
Early online date19 Aug 2017
DOIs
Publication statusEarly online date - 19 Aug 2017

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Coronary Artery Disease
Macular Degeneration
Coronary Angiography
Case-Control Studies
Multivariate Analysis
Randomized Controlled Trials
Smoking

Keywords

  • Journal Article

Cite this

McCarter, Rachel V ; McKay, Gareth J ; Quinn, Nicola B ; Chakravarthy, Usha ; MacGillivray, Tom J ; Robertson, Gavin ; Pellegrini, Enrico ; Trucco, Emanuele ; Williams, Michelle C ; Peto, Tunde ; Dhillon, Baljean ; van Beek, Edwin Jr ; Newby, David E ; Kee, Frank ; Young, Ian S ; Hogg, Ruth E. / Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen. In: British Journal of Ophthalmology. 2017 ; pp. 1-7.
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abstract = "PURPOSE: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort.METHODS: A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angiography (CTCA) underwent ultrawide field (UWF) retinal imaging CAD determined by CTCA and was categorised as normal, non-obstructive or obstructive. Specific AMD features in UWF images were graded. Standardised grids were used to record the spatial location of AMD features, including RPD. Multivariate confounder adjusted regression models assessed the association between RPD and CAD.RESULTS: The 534 participants were aged 27-75 years (mean 58±9 years; 425 (80{\%}) ≥50 years) with a male preponderance (56{\%}). Within the study sample, 178 (33{\%}) had no CAD, 351 (66{\%}) had CAD. RPD was detected in 30 participants (5.6{\%}) and bilaterally in 23. Most participants with bilateral RPD had intermediate AMD 17 (74{\%}). After adjustment for potential confounders (age, sex, drusen >125 µm, smoking status), multivariate analysis found no significant association between CAD and RPD (OR 1.31; 95{\%} CI (0.57 to 3.01); p=0.52). A significant association was identified between RPD and intermediate AMD (OR 3.18; 95{\%} CI (1.61 to 6.27); p=0.001).CONCLUSION: We found no evidence to support an association between CAD and RPD. RPD was strongly associated with intermediate AMD features.TRIAL REGISTRATION NUMBER: NCT01149590, Post results.",
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Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen. / McCarter, Rachel V; McKay, Gareth J; Quinn, Nicola B; Chakravarthy, Usha; MacGillivray, Tom J; Robertson, Gavin; Pellegrini, Enrico; Trucco, Emanuele; Williams, Michelle C; Peto, Tunde; Dhillon, Baljean; van Beek, Edwin Jr; Newby, David E; Kee, Frank; Young, Ian S; Hogg, Ruth E.

In: British Journal of Ophthalmology, 19.08.2017, p. 1-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen

AU - McCarter, Rachel V

AU - McKay, Gareth J

AU - Quinn, Nicola B

AU - Chakravarthy, Usha

AU - MacGillivray, Tom J

AU - Robertson, Gavin

AU - Pellegrini, Enrico

AU - Trucco, Emanuele

AU - Williams, Michelle C

AU - Peto, Tunde

AU - Dhillon, Baljean

AU - van Beek, Edwin Jr

AU - Newby, David E

AU - Kee, Frank

AU - Young, Ian S

AU - Hogg, Ruth E

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2017/8/19

Y1 - 2017/8/19

N2 - PURPOSE: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort.METHODS: A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angiography (CTCA) underwent ultrawide field (UWF) retinal imaging CAD determined by CTCA and was categorised as normal, non-obstructive or obstructive. Specific AMD features in UWF images were graded. Standardised grids were used to record the spatial location of AMD features, including RPD. Multivariate confounder adjusted regression models assessed the association between RPD and CAD.RESULTS: The 534 participants were aged 27-75 years (mean 58±9 years; 425 (80%) ≥50 years) with a male preponderance (56%). Within the study sample, 178 (33%) had no CAD, 351 (66%) had CAD. RPD was detected in 30 participants (5.6%) and bilaterally in 23. Most participants with bilateral RPD had intermediate AMD 17 (74%). After adjustment for potential confounders (age, sex, drusen >125 µm, smoking status), multivariate analysis found no significant association between CAD and RPD (OR 1.31; 95% CI (0.57 to 3.01); p=0.52). A significant association was identified between RPD and intermediate AMD (OR 3.18; 95% CI (1.61 to 6.27); p=0.001).CONCLUSION: We found no evidence to support an association between CAD and RPD. RPD was strongly associated with intermediate AMD features.TRIAL REGISTRATION NUMBER: NCT01149590, Post results.

AB - PURPOSE: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort.METHODS: A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angiography (CTCA) underwent ultrawide field (UWF) retinal imaging CAD determined by CTCA and was categorised as normal, non-obstructive or obstructive. Specific AMD features in UWF images were graded. Standardised grids were used to record the spatial location of AMD features, including RPD. Multivariate confounder adjusted regression models assessed the association between RPD and CAD.RESULTS: The 534 participants were aged 27-75 years (mean 58±9 years; 425 (80%) ≥50 years) with a male preponderance (56%). Within the study sample, 178 (33%) had no CAD, 351 (66%) had CAD. RPD was detected in 30 participants (5.6%) and bilaterally in 23. Most participants with bilateral RPD had intermediate AMD 17 (74%). After adjustment for potential confounders (age, sex, drusen >125 µm, smoking status), multivariate analysis found no significant association between CAD and RPD (OR 1.31; 95% CI (0.57 to 3.01); p=0.52). A significant association was identified between RPD and intermediate AMD (OR 3.18; 95% CI (1.61 to 6.27); p=0.001).CONCLUSION: We found no evidence to support an association between CAD and RPD. RPD was strongly associated with intermediate AMD features.TRIAL REGISTRATION NUMBER: NCT01149590, Post results.

KW - Journal Article

U2 - 10.1136/bjophthalmol-2017-310526

DO - 10.1136/bjophthalmol-2017-310526

M3 - Article

C2 - 28822985

SP - 1

EP - 7

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

ER -