Evaluation of genetic substructure in the Irish Study of High-Density Schizophrenia Families

Patrick F Sullivan, Dermot Walsh, F Anthony O'Neill, Kenneth S Kendler

Research output: Contribution to journalArticlepeer-review

Abstract

The presence of genetic substructure has the potential to diminish the chances of detecting a linkage signal. Using a Markov chain Monte Carlo procedure developed by Pritchard and colleagues and implemented in the program STRUCTURE, we evaluated the evidence for genetic substructure using genotypes from 37 microsatellite markers in affected individuals selected at random from 263 multiplex families in the Irish Study of High-Density Schizophrenia Families. We found no evidence for the presence of genetic substructure in this sample.
Original languageEnglish
Pages (from-to)187-9
Number of pages3
JournalPsychiatric Genetics
Volume14
Issue number4
Publication statusPublished - Dec 2004

Keywords

  • Family
  • Female
  • Genotype
  • Humans
  • Ireland
  • Male
  • Microsatellite Repeats
  • Schizophrenia

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