Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica

Jean Mendes, R.A. Perez-Ecija, R. Zafra, L. Buffoni, A. Martinez-Moreno, John Dalton, G. Mulcahy, J. Perez

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35 Citations (Scopus)

Abstract

Protection against Fasciola hepatica in goats immunized with Peroxiredoxin (Prx) was assessed. The experimental trial consisted of three groups of seven animals: group 1 were unimmunized and uninfected, group 2 were immunized with adjuvant only and group 3 were immunized with recombinant Prx in adjuvant (immunized and infected). Immunization with Prx in Quil A adjuvant, group 3, induced a reduction in fluke burden of 33.04% when compared to adjuvant control, group 2, although this difference was not significant. The hepatic gross and microscopical morphometric study revealed lower damage in the Prx-immunized compared to group 2 (p
Original languageEnglish
Pages (from-to)2832-2840
Number of pages9
JournalVaccine
Volume28
Issue number16
DOIs
Publication statusPublished - 01 Apr 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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    Mendes, J., Perez-Ecija, R. A., Zafra, R., Buffoni, L., Martinez-Moreno, A., Dalton, J., Mulcahy, G., & Perez, J. (2010). Evaluation of hepatic changes and local and systemic immune responses in goats immunized with recombinant Peroxiredoxin (Prx) and challenged with Fasciola hepatica. Vaccine, 28(16), 2832-2840. https://doi.org/10.1016/j.vaccine.2010.01.055