Evaluation of the effect of wheat aleurone-rich foods on markers of antioxidant status, inflammation and endothelial function in apparently healthy men and women

Ruth K Price, Julie M W Wallace, Lesley L Hamill, Edel M Keaveney, J J Strain, Michael J Parker, Robert W Welch

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Observational data show an inverse association between the consumption of whole-grain foods, and inflammation and related diseases. Although the underlying mechanisms are unclear, whole grains, and in particular the aleurone layer, contain a wide range of components with putative antioxidant and anti-inflammatory effects. We evaluated the effects of a diet high in wheat aleurone on plasma antioxidants status, markers of inflammation and endothelial function. In this parallel, participant-blinded intervention, seventy-nine healthy, older, overweight participants (45-65 years, BMI>25 kg/m²) incorporated either aleurone-rich cereal products (27 g aleurone/d), or control products balanced for fibre and macronutrients, into their habitual diets for 4 weeks. Fasting blood samples were taken at baseline and on day 29. Results showed that, compared to control, consumption of aleurone-rich products provided substantial amounts of micronutrients and phytochemicals which may function as antioxidants. Additionally, incorporating these products into a habitual diet resulted in significantly lower plasma concentrations of the inflammatory marker, C-reactive protein (P = 0·035), which is an independent risk factor for CVD. However, no changes were observed in other markers of inflammation, antioxidant status or endothelial function. These results provide a possible mechanism underlying the beneficial effects of longer-term whole-grain intake. However, it is unclear whether this effect is owing to a specific component, or a combination of components in wheat aleurone.
Original languageEnglish
Pages (from-to)1644-51
Number of pages8
JournalBritish Journal of Nutrition
Volume108
Issue number9
DOIs
Publication statusPublished - 14 Nov 2012

Keywords

  • Aged
  • Aging
  • Antioxidants
  • Biological Markers
  • Body Mass Index
  • C-Reactive Protein
  • Dietary Fiber
  • Dietary Proteins
  • Endosperm
  • Endothelium, Vascular
  • Female
  • Food, Fortified
  • Humans
  • Male
  • Micronutrients
  • Middle Aged
  • Overweight
  • Seed Storage Proteins
  • Single-Blind Method
  • Triticum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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