Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Lisa Wang; Michael G. Heckman; Jan O. Aasly; Grazia Annesi; Maria Bozi; Sun Ju Chung; Carl Clarke; David Crosiers; Gertrud Eckstein; Gaetan Garraux; Georgios M. Hadjigeorgiou; Nobu Hattori; Beom Jeon; Yun J. Kim; Masato Kubo; Suzanne Lesage; Juei Jueng Lin; Timothy Lynch; Peter Lichtner; George D. Mellick; Vincent Mok; Karen Morrison; Aldo Quattrone; Wataru Satake; Peter A. Silburn; Leonidas Stefanis; Joanne D. Stockton; Eng King Tan; Tatsushi Toda; Alexis Brice; Christine Van Broeckhoven; Ryan J. Uitti; Karin Wirdefeldt; Zbigniew Wszolek; Georgia Xiromerisiou; Demetrius M. Maraganore; Thomas Gasser; Rejko Krüger; Matthew J. Farrer; Owen A. Ross; Manu Sharma; GEOPD Consortium

doi:10.1016/j.neurobiolaging.2016.09.022

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Lisa Wang, Michael G. Heckman, Jan O. Aasly, Grazia Annesi, Maria Bozi, Sun Ju Chung, Carl Clarke, David Crosiers, Gertrud Eckstein, Gaetan Garraux, Georgios M. Hadjigeorgiou, Nobu Hattori, Beom Jeon, Yun J. Kim, Masato Kubo, Suzanne Lesage, Juei Jueng Lin, Timothy Lynch, Peter Lichtner, George D. MellickVincent Mok, Karen Morrison, Aldo Quattrone, Wataru Satake, Peter A. Silburn, Leonidas Stefanis, Joanne D. Stockton, Eng King Tan, Tatsushi Toda, Alexis Brice, Christine Van Broeckhoven, Ryan J. Uitti, Karin Wirdefeldt, Zbigniew Wszolek, Georgia Xiromerisiou, Demetrius M. Maraganore, Thomas Gasser, Rejko Krüger, Matthew J. Farrer, Owen A. Ross, Manu Sharma, GEOPD Consortium

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted

Original language	English
Pages (from-to)	217.e1-217.e4
Number of pages	4
Journal	Neurobiology of Aging
Volume	49
Early online date	06 Oct 2016
DOIs	https://doi.org/10.1016/j.neurobiolaging.2016.09.022
Publication status	Published - Jan 2017
Externally published	Yes

Bibliographical note

Keywords

Epistasis, Genetic/genetics
Genetic Association Studies
Genetic Loci/genetics
Genetic Predisposition to Disease/genetics
Genetic Variation/genetics
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics
Multicenter Studies as Topic
Parkinson Disease/genetics
Risk

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Wang, L., Heckman, M. G., Aasly, J. O., Annesi, G., Bozi, M., Chung, S. J., Clarke, C., Crosiers, D., Eckstein, G., Garraux, G., Hadjigeorgiou, G. M., Hattori, N., Jeon, B., Kim, Y. J., Kubo, M., Lesage, S., Lin, J. J., Lynch, T., Lichtner, P., ... GEOPD Consortium (2017). Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study. Neurobiology of Aging, 49, 217.e1-217.e4. https://doi.org/10.1016/j.neurobiolaging.2016.09.022

@article{8ab1a7f4da7c4f2abb9fe48af9b5108b,

title = "Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study",

abstract = "A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted",

keywords = "Epistasis, Genetic/genetics, Genetic Association Studies, Genetic Loci/genetics, Genetic Predisposition to Disease/genetics, Genetic Variation/genetics, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics, Multicenter Studies as Topic, Parkinson Disease/genetics, Risk",

author = "Lisa Wang and Heckman, {Michael G.} and Aasly, {Jan O.} and Grazia Annesi and Maria Bozi and Chung, {Sun Ju} and Carl Clarke and David Crosiers and Gertrud Eckstein and Gaetan Garraux and Hadjigeorgiou, {Georgios M.} and Nobu Hattori and Beom Jeon and Kim, {Yun J.} and Masato Kubo and Suzanne Lesage and Lin, {Juei Jueng} and Timothy Lynch and Peter Lichtner and Mellick, {George D.} and Vincent Mok and Karen Morrison and Aldo Quattrone and Wataru Satake and Silburn, {Peter A.} and Leonidas Stefanis and Stockton, {Joanne D.} and Tan, {Eng King} and Tatsushi Toda and Alexis Brice and {Van Broeckhoven}, Christine and Uitti, {Ryan J.} and Karin Wirdefeldt and Zbigniew Wszolek and Georgia Xiromerisiou and Maraganore, {Demetrius M.} and Thomas Gasser and Rejko Kr{\"u}ger and Farrer, {Matthew J.} and Ross, {Owen A.} and Manu Sharma and {GEOPD Consortium}",

year = "2017",

month = jan,

doi = "10.1016/j.neurobiolaging.2016.09.022",

language = "English",

volume = "49",

pages = "217.e1--217.e4",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

}

Wang, L, Heckman, MG, Aasly, JO, Annesi, G, Bozi, M, Chung, SJ, Clarke, C, Crosiers, D, Eckstein, G, Garraux, G, Hadjigeorgiou, GM, Hattori, N, Jeon, B, Kim, YJ, Kubo, M, Lesage, S, Lin, JJ, Lynch, T, Lichtner, P, Mellick, GD, Mok, V, Morrison, K, Quattrone, A, Satake, W, Silburn, PA, Stefanis, L, Stockton, JD, Tan, EK, Toda, T, Brice, A, Van Broeckhoven, C, Uitti, RJ, Wirdefeldt, K, Wszolek, Z, Xiromerisiou, G, Maraganore, DM, Gasser, T, Krüger, R, Farrer, MJ, Ross, OA, Sharma, M & GEOPD Consortium 2017, 'Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study', Neurobiology of Aging, vol. 49, pp. 217.e1-217.e4. https://doi.org/10.1016/j.neurobiolaging.2016.09.022

TY - JOUR

T1 - Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

AU - Wang, Lisa

AU - Heckman, Michael G.

AU - Aasly, Jan O.

AU - Annesi, Grazia

AU - Bozi, Maria

AU - Chung, Sun Ju

AU - Clarke, Carl

AU - Crosiers, David

AU - Eckstein, Gertrud

AU - Garraux, Gaetan

AU - Hadjigeorgiou, Georgios M.

AU - Hattori, Nobu

AU - Jeon, Beom

AU - Kim, Yun J.

AU - Kubo, Masato

AU - Lesage, Suzanne

AU - Lin, Juei Jueng

AU - Lynch, Timothy

AU - Lichtner, Peter

AU - Mellick, George D.

AU - Mok, Vincent

AU - Morrison, Karen

AU - Quattrone, Aldo

AU - Satake, Wataru

AU - Silburn, Peter A.

AU - Stefanis, Leonidas

AU - Stockton, Joanne D.

AU - Tan, Eng King

AU - Toda, Tatsushi

AU - Brice, Alexis

AU - Van Broeckhoven, Christine

AU - Uitti, Ryan J.

AU - Wirdefeldt, Karin

AU - Wszolek, Zbigniew

AU - Xiromerisiou, Georgia

AU - Maraganore, Demetrius M.

AU - Gasser, Thomas

AU - Krüger, Rejko

AU - Farrer, Matthew J.

AU - Ross, Owen A.

AU - Sharma, Manu

AU - GEOPD Consortium

PY - 2017/1

Y1 - 2017/1

N2 - A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted

AB - A recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted

KW - Epistasis, Genetic/genetics

KW - Genetic Association Studies

KW - Genetic Loci/genetics

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Variation/genetics

KW - Humans

KW - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics

KW - Multicenter Studies as Topic

KW - Parkinson Disease/genetics

KW - Risk

U2 - 10.1016/j.neurobiolaging.2016.09.022

DO - 10.1016/j.neurobiolaging.2016.09.022

M3 - Article

C2 - 27814993

SN - 0197-4580

VL - 49

SP - 217.e1-217.e4

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

Abstract

Bibliographical note

Keywords

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