Evidence for altered ETB receptor characterisitics during development and progression of ventricular cardiomyocyte hypertrophy.

G.R. Lee, David Bell, Elizabeth Kelso, C.C.H. Argent, Barbara McDermott

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The hypothesis that endothelin (ET) receptor mechanisms are altered during development and progression of left ventricular hypertrophy (LVH) in vivo was tested using spontaneously hypertensive rats (SHRs). Ventricular cardiomyocytes were isolated from SHRs before onset (8 and 12 wk) and during progression (16, 20, and 24 wk) of LVH and compared with age-matched normotensive Wistar-Kyoto (WKY) rats. PreproET-1 mRNA expression was elevated in SHR (P
Original languageEnglish
Pages (from-to)H425-H432
Number of pages8
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume287
Issue number1 56-1
DOIs
Publication statusPublished - Jul 2004

ASJC Scopus subject areas

  • Physiology

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