Ex vivo diagnosis of lung cancer using a Raman miniprobe.

Nicholas Magee, S. Villaumie Julien, T. Marple Eric, Madeleine Ennis, Stuart Elborn, John McGarvey

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)


Lung cancer is the most common cause of cancer death. The conventional method of confirming the diagnosis is bronchoscopy, inspecting the airways of the patient with a fiber optic endoscope. A number of studies have shown that Raman spectroscopy can diagnose lung cancer in vitro. In this study, Raman spectra were obtained from ex vivo normal and malignant lung tissue using a minifiber optic Raman probe suitable for insertion into the working channel of a bronchoscope. Shifted subtracted Raman spectroscopy was used to reduce the fluorescence from the lung tissue. Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo.
Original languageEnglish
Pages (from-to)8137-8141
Number of pages5
JournalThe Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical
Issue number23
Publication statusPublished - 11 Jun 2009

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Surfaces, Coatings and Films


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