Abstract
Lung cancer is the most common cause of cancer death. The conventional method of confirming the diagnosis is bronchoscopy, inspecting the airways of the patient with a fiber optic endoscope. A number of studies have shown that Raman spectroscopy can diagnose lung cancer in vitro. In this study, Raman spectra were obtained from ex vivo normal and malignant lung tissue using a minifiber optic Raman probe suitable for insertion into the working channel of a bronchoscope. Shifted subtracted Raman spectroscopy was used to reduce the fluorescence from the lung tissue. Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 8137-8141 |
| Number of pages | 5 |
| Journal | The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical |
| Volume | 113(23) |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - 11 Jun 2009 |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Materials Chemistry
- Surfaces, Coatings and Films
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Cite this
Magee, N., Villaumie Julien, S., Marple Eric, T., Ennis, M., Elborn, S., & McGarvey, J. (2009). Ex vivo diagnosis of lung cancer using a Raman miniprobe. The Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical, 113(23)(23), 8137-8141. https://doi.org/10.1021/jp900379w