Ex vivo diagnosis of lung cancer using a Raman miniprobe.

Nicholas Magee, S. Villaumie Julien, T. Marple Eric, Madeleine Ennis, Stuart Elborn, John McGarvey

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Lung cancer is the most common cause of cancer death. The conventional method of confirming the diagnosis is bronchoscopy, inspecting the airways of the patient with a fiber optic endoscope. A number of studies have shown that Raman spectroscopy can diagnose lung cancer in vitro. In this study, Raman spectra were obtained from ex vivo normal and malignant lung tissue using a minifiber optic Raman probe suitable for insertion into the working channel of a bronchoscope. Shifted subtracted Raman spectroscopy was used to reduce the fluorescence from the lung tissue. Using principal component analysis with a leave-one-out analysis, the tissues were classified accurately. This novel technique has the potential to obtain Raman spectra from tumors from patients with lung cancer in vivo.
Original languageEnglish
Pages (from-to)8137-8141
Number of pages5
JournalThe Journal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical
Volume113(23)
Issue number23
DOIs
Publication statusPublished - 11 Jun 2009

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Surfaces, Coatings and Films

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