Mepolizumab, a humanised monoclonal antibody that neutralises interleukin-5, reduces exacerbations of severe eosinophilic asthma and chronic obstructive pulmonary disease (COPD) [1, 2]. The beneficial effect of treatment is most obvious in patients with a raised peripheral blood eosinophil count, a group who are at high risk of exacerbation off treatment [2, 3]. Even in this population, exacerbation rates whilst receiving mepolizumab are around one per patient per year. The nature of these remaining exacerbations has not been described. We carried out a post hoc comparison of exacerbations occurring during treatment with mepolizumab or placebo in a previously reported, double-blind, placebo-controlled trial of mepolizumab in severe eosinophilic asthma . We tested the hypothesis that exacerbations in each group differ with respect to change in symptom scores, forced expiratory volume in 1 s (FEV1) and inflammatory profile.
- Anti-Asthmatic Agents/administration & dosage
- Antibodies, Monoclonal, Humanized/administration & dosage
- Disease Progression
- Double-Blind Method
- Treatment Outcome
Shrimanker, R., Pavord, I. D., Yancey, S., Heaney, L. G., Green, R. H., Bradding, P., Hargadon, B., Brightling, C. E., Wardlaw, A. J., & Haldar, P. (2018). Exacerbations of severe asthma in patients treated with mepolizumab. European Respiratory Journal, 52(6). https://doi.org/10.1183/13993003.01127-2018