Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits

Juan C Piña-Crespo; Maria Talantova; Ileana Micu; Bradley States; H-S Vincent Chen; Shichun Tu; Nobuki Nakanishi; Gary Tong; Dongxian Zhang; Stephen F Heinemann; Gerald W Zamponi; Peter K Stys; Stuart A Lipton

doi:10.1523/JNEUROSCI.1593-10.2010

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits

Juan C Piña-Crespo, Maria Talantova, Ileana Micu, Bradley States, H-S Vincent Chen, Shichun Tu, Nobuki Nakanishi, Gary Tong, Dongxian Zhang, Stephen F Heinemann, Gerald W Zamponi, Peter K Stys, Stuart A Lipton

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.

Original language	English
Pages (from-to)	11501-5
Number of pages	5
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume	30
Issue number	34
DOIs	https://doi.org/10.1523/JNEUROSCI.1593-10.2010
Publication status	Published - 25 Aug 2010

Keywords

myelin
Cell Line
Central Nervous System/physiology
Excitatory Postsynaptic Potentials/physiology
Glycine/physiology
Humans
Mice
Mice, Knockout
Myelin Sheath/physiology
Protein Subunits/agonists
Rats
Rats, Long-Evans
Receptors, N-Methyl-D-Aspartate/agonists
Recombinant Proteins/agonists
calcium

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10.1523/JNEUROSCI.1593-10.2010

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Piña-Crespo, J. C., Talantova, M., Micu, I., States, B., Chen, H-S. V., Tu, S., Nakanishi, N., Tong, G., Zhang, D., Heinemann, S. F., Zamponi, G. W., Stys, P. K., & Lipton, S. A. (2010). Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(34), 11501-5. https://doi.org/10.1523/JNEUROSCI.1593-10.2010

Piña-Crespo, Juan C ; Talantova, Maria ; Micu, Ileana ; States, Bradley ; Chen, H-S Vincent ; Tu, Shichun ; Nakanishi, Nobuki ; Tong, Gary ; Zhang, Dongxian ; Heinemann, Stephen F ; Zamponi, Gerald W ; Stys, Peter K ; Lipton, Stuart A. / Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 ; Vol. 30, No. 34. pp. 11501-5.

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title = "Excitatory glycine responses of CNS myelin mediated by NR1/NR3 {"}NMDA{"} receptor subunits",

abstract = "NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 {"}NMDA{"} receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.",

keywords = "myelin, Cell Line, Central Nervous System/physiology, Excitatory Postsynaptic Potentials/physiology, Glycine/physiology, Humans, Mice, Mice, Knockout, Myelin Sheath/physiology, Protein Subunits/agonists, Rats, Rats, Long-Evans, Receptors, N-Methyl-D-Aspartate/agonists, Recombinant Proteins/agonists, calcium",

author = "Pi{\~n}a-Crespo, {Juan C} and Maria Talantova and Ileana Micu and Bradley States and Chen, {H-S Vincent} and Shichun Tu and Nobuki Nakanishi and Gary Tong and Dongxian Zhang and Heinemann, {Stephen F} and Zamponi, {Gerald W} and Stys, {Peter K} and Lipton, {Stuart A}",

year = "2010",

month = aug,

day = "25",

doi = "10.1523/JNEUROSCI.1593-10.2010",

language = "English",

volume = "30",

pages = "11501--5",

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Piña-Crespo, JC, Talantova, M, Micu, I, States, B, Chen, H-SV, Tu, S, Nakanishi, N, Tong, G, Zhang, D, Heinemann, SF, Zamponi, GW, Stys, PK & Lipton, SA 2010, 'Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 30, no. 34, pp. 11501-5. https://doi.org/10.1523/JNEUROSCI.1593-10.2010

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. / Piña-Crespo, Juan C; Talantova, Maria; Micu, Ileana; States, Bradley; Chen, H-S Vincent; Tu, Shichun; Nakanishi, Nobuki; Tong, Gary; Zhang, Dongxian; Heinemann, Stephen F; Zamponi, Gerald W; Stys, Peter K; Lipton, Stuart A.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, No. 34, 25.08.2010, p. 11501-5.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits

AU - Piña-Crespo, Juan C

AU - Talantova, Maria

AU - Micu, Ileana

AU - States, Bradley

AU - Chen, H-S Vincent

AU - Tu, Shichun

AU - Nakanishi, Nobuki

AU - Tong, Gary

AU - Zhang, Dongxian

AU - Heinemann, Stephen F

AU - Zamponi, Gerald W

AU - Stys, Peter K

AU - Lipton, Stuart A

PY - 2010/8/25

Y1 - 2010/8/25

N2 - NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.

AB - NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.

KW - myelin

KW - Cell Line

KW - Central Nervous System/physiology

KW - Excitatory Postsynaptic Potentials/physiology

KW - Glycine/physiology

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Myelin Sheath/physiology

KW - Protein Subunits/agonists

KW - Rats

KW - Rats, Long-Evans

KW - Receptors, N-Methyl-D-Aspartate/agonists

KW - Recombinant Proteins/agonists

KW - calcium

U2 - 10.1523/JNEUROSCI.1593-10.2010

DO - 10.1523/JNEUROSCI.1593-10.2010

M3 - Article

C2 - 20739572

VL - 30

SP - 11501

EP - 11505

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 34

ER -

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits

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Keywords

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