Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits

Juan C Piña-Crespo, Maria Talantova, Ileana Micu, Bradley States, H-S Vincent Chen, Shichun Tu, Nobuki Nakanishi, Gary Tong, Dongxian Zhang, Stephen F Heinemann, Gerald W Zamponi, Peter K Stys, Stuart A Lipton

    Research output: Contribution to journalArticlepeer-review

    69 Citations (Scopus)


    NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.

    Original languageEnglish
    Pages (from-to)11501-5
    Number of pages5
    JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
    Issue number34
    Publication statusPublished - 25 Aug 2010


    • myelin
    • Cell Line
    • Central Nervous System/physiology
    • Excitatory Postsynaptic Potentials/physiology
    • Glycine/physiology
    • Humans
    • Mice
    • Mice, Knockout
    • Myelin Sheath/physiology
    • Protein Subunits/agonists
    • Rats
    • Rats, Long-Evans
    • Receptors, N-Methyl-D-Aspartate/agonists
    • Recombinant Proteins/agonists
    • calcium


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