Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank

Jessica Petrick; Úna McMenamin; Xuehong Zhang; Anne Zeleniuch-Jacquotte; Jean  Wactawski-Wende; Tracey G. Simon; Rashmi  Sinha; Howard D.  Sesso; Catherine  Schairer; Lynn  Rosenberg; Thomas E.  Rohan; Kim  Robien; Mark P.  Purdue; Jenny N.  Poynter; Julie R.  Palmer; Yunxia  Lu; Martha S.  Linet; I-Min  Lee; Jill  Koshiol; Cari M.  Kitahara; Victoria A.  Kirsh; Jonathan N.  Hoffman; Barry I.  Graubard; Edward  Giovannucci; J. Michael  Gaziano; Susan M.  Gapstur; Neal D.  Freedman; Andrea A.  Florio; Dawn Q.  Chong; Yu  Chen; Andrew T.  Chan; Julie E.  Buring; Laura E. Beane  Freeman; Jennifer W.  Bea; Christopher R.  Cardwell; Peter T.  Campbell; Katherine A.  McGlynn

Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank

Jessica Petrick, Úna McMenamin, Xuehong Zhang, Anne Zeleniuch-Jacquotte, Jean Wactawski-Wende, Tracey G. Simon, Rashmi Sinha, Howard D. Sesso, Catherine Schairer, Lynn Rosenberg, Thomas E. Rohan, Kim Robien, Mark P. Purdue, Jenny N. Poynter, Julie R. Palmer, Yunxia Lu, Martha S. Linet, I-Min Lee, Jill Koshiol, Cari M. KitaharaVictoria A. Kirsh, Jonathan N. Hoffman, Barry I. Graubard, Edward Giovannucci, J. Michael Gaziano, Susan M. Gapstur, Neal D. Freedman, Andrea A. Florio, Dawn Q. Chong, Yu Chen, Andrew T. Chan, Julie E. Buring, Laura E. Beane Freeman, Jennifer W. Bea, Christopher R. Cardwell, Peter T. Campbell, Katherine A. McGlynn

School of Medicine, Dentistry and Biomedical Sciences

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Abstract

Background: Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both estrogen receptor-α and -β, and estrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating estradiol is associated with increased ICC risk, further supporting a hormonal etiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC.

Methods: We harmonized data from 1,107,498 women who enrolled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from LCPP (n=180 cases) and the UK Biobank (n=57 cases).

Results: Hysterectomy was associated with a doubling of ICC risk (HR=1.98,95%CI:1.27–3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR=1.62,95%CI:1.03–2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors.

Conclusions: This study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.

Original language	English
Number of pages	9
Journal	British Journal of Cancer
Early online date	07 May 2020
Publication status	Early online date - 07 May 2020

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Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank
© 2020 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank
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Petrick, J., McMenamin, Ú., Zhang, X., Zeleniuch-Jacquotte, A., Wactawski-Wende, J., Simon, T. G., Sinha, R., Sesso, H. D., Schairer, C., Rosenberg, L., Rohan, T. E., Robien, K., Purdue, M. P., Poynter, J. N., Palmer, J. R., Lu, Y., Linet, M. S., Lee, I-M., Koshiol, J., ... McGlynn, K. A. (2020). Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank. British Journal of Cancer.

Petrick, Jessica ; McMenamin, Úna ; Zhang, Xuehong ; Zeleniuch-Jacquotte, Anne ; Wactawski-Wende, Jean ; Simon, Tracey G. ; Sinha, Rashmi ; Sesso, Howard D. ; Schairer, Catherine ; Rosenberg, Lynn ; Rohan, Thomas E. ; Robien, Kim ; Purdue, Mark P. ; Poynter, Jenny N. ; Palmer, Julie R. ; Lu, Yunxia ; Linet, Martha S. ; Lee, I-Min ; Koshiol, Jill ; Kitahara, Cari M. ; Kirsh, Victoria A. ; Hoffman, Jonathan N. ; Graubard, Barry I. ; Giovannucci, Edward ; Gaziano, J. Michael ; Gapstur, Susan M. ; Freedman, Neal D. ; Florio, Andrea A. ; Chong, Dawn Q. ; Chen, Yu ; Chan, Andrew T. ; Buring, Julie E. ; Freeman, Laura E. Beane ; Bea, Jennifer W. ; Cardwell, Christopher R. ; Campbell, Peter T. ; McGlynn, Katherine A. . / Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank. In: British Journal of Cancer. 2020.

@article{dfa3d73877c7472b9119e02b79a3d14d,

title = "Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank",

abstract = "Background: Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both estrogen receptor-α and -β, and estrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating estradiol is associated with increased ICC risk, further supporting a hormonal etiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC. Methods: We harmonized data from 1,107,498 women who enrolled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from LCPP (n=180 cases) and the UK Biobank (n=57 cases). Results: Hysterectomy was associated with a doubling of ICC risk (HR=1.98,95%CI:1.27–3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR=1.62,95%CI:1.03–2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors. Conclusions: This study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk. ",

author = "Jessica Petrick and {\'U}na McMenamin and Xuehong Zhang and Anne Zeleniuch-Jacquotte and Jean Wactawski-Wende and Simon, {Tracey G.} and Rashmi Sinha and Sesso, {Howard D.} and Catherine Schairer and Lynn Rosenberg and Rohan, {Thomas E.} and Kim Robien and Purdue, {Mark P.} and Poynter, {Jenny N.} and Palmer, {Julie R.} and Yunxia Lu and Linet, {Martha S.} and I-Min Lee and Jill Koshiol and Kitahara, {Cari M.} and Kirsh, {Victoria A.} and Hoffman, {Jonathan N.} and Graubard, {Barry I.} and Edward Giovannucci and Gaziano, {J. Michael} and Gapstur, {Susan M.} and Freedman, {Neal D.} and Florio, {Andrea A.} and Chong, {Dawn Q.} and Yu Chen and Chan, {Andrew T.} and Buring, {Julie E.} and Freeman, {Laura E. Beane} and Bea, {Jennifer W.} and Cardwell, {Christopher R.} and Campbell, {Peter T.} and McGlynn, {Katherine A.}",

year = "2020",

month = may,

day = "7",

language = "English",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

}

Petrick, J, McMenamin, Ú, Zhang, X, Zeleniuch-Jacquotte, A, Wactawski-Wende, J, Simon, TG, Sinha, R, Sesso, HD, Schairer, C, Rosenberg, L, Rohan, TE, Robien, K, Purdue, MP, Poynter, JN, Palmer, JR, Lu, Y, Linet, MS, Lee, I-M, Koshiol, J, Kitahara, CM, Kirsh, VA, Hoffman, JN, Graubard, BI, Giovannucci, E, Gaziano, JM, Gapstur, SM, Freedman, ND, Florio, AA, Chong, DQ, Chen, Y, Chan, AT, Buring, JE, Freeman, LEB, Bea, JW, Cardwell, CR, Campbell, PT & McGlynn, KA 2020, 'Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank', British Journal of Cancer.

Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank. / Petrick, Jessica; McMenamin, Úna; Zhang, Xuehong; Zeleniuch-Jacquotte, Anne; Wactawski-Wende, Jean ; Simon, Tracey G.; Sinha, Rashmi ; Sesso, Howard D. ; Schairer, Catherine ; Rosenberg, Lynn ; Rohan, Thomas E. ; Robien, Kim ; Purdue, Mark P. ; Poynter, Jenny N. ; Palmer, Julie R. ; Lu, Yunxia ; Linet, Martha S. ; Lee, I-Min ; Koshiol, Jill ; Kitahara, Cari M. ; Kirsh, Victoria A. ; Hoffman, Jonathan N. ; Graubard, Barry I. ; Giovannucci, Edward ; Gaziano, J. Michael ; Gapstur, Susan M. ; Freedman, Neal D. ; Florio, Andrea A. ; Chong, Dawn Q. ; Chen, Yu ; Chan, Andrew T. ; Buring, Julie E. ; Freeman, Laura E. Beane ; Bea, Jennifer W. ; Cardwell, Christopher R. ; Campbell, Peter T. ; McGlynn, Katherine A. .

In: British Journal of Cancer, 07.05.2020.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Exogenous Hormone Use, Reproductive Factors and Risk of Intrahepatic Cholangiocarcinoma among Women: Results from Cohort Studies in the Liver Cancer Pooling Project and UK Biobank

AU - Petrick, Jessica

AU - McMenamin, Úna

AU - Zhang, Xuehong

AU - Zeleniuch-Jacquotte, Anne

AU - Wactawski-Wende, Jean

AU - Simon, Tracey G.

AU - Sinha, Rashmi

AU - Sesso, Howard D.

AU - Schairer, Catherine

AU - Rosenberg, Lynn

AU - Rohan, Thomas E.

AU - Robien, Kim

AU - Purdue, Mark P.

AU - Poynter, Jenny N.

AU - Palmer, Julie R.

AU - Lu, Yunxia

AU - Linet, Martha S.

AU - Lee, I-Min

AU - Koshiol, Jill

AU - Kitahara, Cari M.

AU - Kirsh, Victoria A.

AU - Hoffman, Jonathan N.

AU - Graubard, Barry I.

AU - Giovannucci, Edward

AU - Gaziano, J. Michael

AU - Gapstur, Susan M.

AU - Freedman, Neal D.

AU - Florio, Andrea A.

AU - Chong, Dawn Q.

AU - Chen, Yu

AU - Chan, Andrew T.

AU - Buring, Julie E.

AU - Freeman, Laura E. Beane

AU - Bea, Jennifer W.

AU - Cardwell, Christopher R.

AU - Campbell, Peter T.

AU - McGlynn, Katherine A.

PY - 2020/5/7

Y1 - 2020/5/7

N2 - Background: Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both estrogen receptor-α and -β, and estrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating estradiol is associated with increased ICC risk, further supporting a hormonal etiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC. Methods: We harmonized data from 1,107,498 women who enrolled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from LCPP (n=180 cases) and the UK Biobank (n=57 cases). Results: Hysterectomy was associated with a doubling of ICC risk (HR=1.98,95%CI:1.27–3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR=1.62,95%CI:1.03–2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors. Conclusions: This study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.

AB - Background: Intrahepatic cholangiocarcinoma (ICC) arises from cholangiocytes in the intrahepatic bile duct and is the second most common type of liver cancer. Cholangiocytes express both estrogen receptor-α and -β, and estrogens positively modulate cholangiocyte proliferation. Studies in women and men have reported higher circulating estradiol is associated with increased ICC risk, further supporting a hormonal etiology. However, no observational studies have examined the associations between exogenous hormone use and reproductive factors, as proxies of endogenous hormone levels, and risk of ICC. Methods: We harmonized data from 1,107,498 women who enrolled in 12 North American-based cohort studies (in the Liver Cancer Pooling Project, LCPP) and the UK Biobank between 1980-1998 and 2006-2010, respectively. Cox proportional hazards regression models were used to generate hazard ratios (HR) and 95% confidence internals (CI). Then, meta-analytic techniques were used to combine the estimates from LCPP (n=180 cases) and the UK Biobank (n=57 cases). Results: Hysterectomy was associated with a doubling of ICC risk (HR=1.98,95%CI:1.27–3.09), compared to women aged 50-54 at natural menopause. Long-term oral contraceptive use (9+ years) was associated with a 62% increased ICC risk (HR=1.62,95%CI:1.03–2.55). There was no association between ICC risk and other exogenous hormone use or reproductive factors. Conclusions: This study suggests that hysterectomy and long-term oral contraceptive use may be associated with an increased ICC risk.

M3 - Article

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

ER -