Exosomes for protein and peptide drug delivery

Dhwani Rana, Nimeet Desai, Sagar Salave, Lalitkumar K. Vora

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Exosomes, the smallest extracellular vesicles, are emerging as powerful vehicles for the targeted delivery of protein and peptide therapeutics. Originating from endosomal compartments, these vesicles excel in intercellular communication and can transport a variety of biological molecules, making them highly suitable for therapeutic use. This chapter focuses on the utilization of exosomes for delivering proteins and peptides, exploring their biogenesis, and detailing methods such as incubation, electroporation, and sonication for loading these therapeutic agents. Key studies illustrate the successful application of exosomes in crossing biological barriers, such as the blood-brain barrier, to deliver targeted treatments for diseases including cancer and inflammatory conditions. Despite challenges like the heterogeneity of exosomes and difficulties in their isolation and purification, the chapter highlights strategies to overcome these obstacles and enhance protein/peptide efficiency. Emphasizing the potential of exosomes to revolutionize protein and peptide delivery systems, this chapter provides insights into future directions that could further harness their clinical applications, demonstrating their pivotal role in advancing therapeutic strategies.

Original languageEnglish
Title of host publicationExosome communication. Advances in research and therapeutics for health and disease
EditorsDalapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C. Cho
PublisherElsevier Inc.
Chapter12
Pages305-327
Number of pages23
ISBN (Electronic)9780443290527
ISBN (Print)9780443290534
DOIs
Publication statusPublished - 29 Nov 2024

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Inc. All rights reserved.

Keywords

  • Biotherapeutics
  • Exosome
  • Extracellular vesicles
  • Peptide delivery
  • Protein delivery

ASJC Scopus subject areas

  • General Medicine
  • General Pharmacology, Toxicology and Pharmaceutics

Fingerprint

Dive into the research topics of 'Exosomes for protein and peptide drug delivery'. Together they form a unique fingerprint.

Cite this