Exosomes nanovesicles for gene delivery and vaccination

Nimeet Desai, Shreya Pande, Sagar Salave, Lalitkumar K. Vora

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter delves into the growing field of utilizing exosomes as nanocarriers for gene and vaccine delivery. Commencing with an examination of the fundamental characteristics of exosomes, such as cellular targeting, stability, and immunomodulatory properties, the narrative traverses the intricate landscape of engineering strategies employed for payload loading and improved delivery. Subsequently, it elucidates the latest reports on using exosomes for gene delivery, demonstrating their efficacy in transporting mRNA, siRNA/miRNA, and even CRISPR-Cas9 for precise therapeutic interventions. Furthermore, the chapter delves into the application of exosomes in vaccination, shedding light on their interactions with the immune system and inherent immunomodulatory features. The current clinical status of exosome-based platforms and the existing challenges are also meticulously examined. In summary, this chapter furnishes a comprehensive overview of exosome-based gene and vaccine delivery platforms, emphasizing their potential to catalyze transformative advancements in biomedical research and clinical practice.

Original languageEnglish
Title of host publicationExosome communication. Advances in research and therapeutics for health and disease
EditorsDalapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C. Cho
PublisherElsevier Inc.
Chapter13
Pages329-374
Number of pages46
ISBN (Electronic)9780443290527
ISBN (Print)9780443290534
DOIs
Publication statusPublished - 29 Nov 2024

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Inc. All rights reserved.

Keywords

  • Exosome
  • Gene delivery
  • Gene therapy
  • Vaccination
  • Vaccine

ASJC Scopus subject areas

  • General Medicine
  • General Pharmacology, Toxicology and Pharmaceutics

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