Abstract
This chapter delves into the growing field of utilizing exosomes as nanocarriers for gene and vaccine delivery. Commencing with an examination of the fundamental characteristics of exosomes, such as cellular targeting, stability, and immunomodulatory properties, the narrative traverses the intricate landscape of engineering strategies employed for payload loading and improved delivery. Subsequently, it elucidates the latest reports on using exosomes for gene delivery, demonstrating their efficacy in transporting mRNA, siRNA/miRNA, and even CRISPR-Cas9 for precise therapeutic interventions. Furthermore, the chapter delves into the application of exosomes in vaccination, shedding light on their interactions with the immune system and inherent immunomodulatory features. The current clinical status of exosome-based platforms and the existing challenges are also meticulously examined. In summary, this chapter furnishes a comprehensive overview of exosome-based gene and vaccine delivery platforms, emphasizing their potential to catalyze transformative advancements in biomedical research and clinical practice.
Original language | English |
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Title of host publication | Exosome communication. Advances in research and therapeutics for health and disease |
Editors | Dalapathi Gugulothu, Dharmendra Kumar Khatri, Lalitkumar K. Vora, William C. Cho |
Publisher | Elsevier Inc. |
Chapter | 13 |
Pages | 329-374 |
Number of pages | 46 |
ISBN (Electronic) | 9780443290527 |
ISBN (Print) | 9780443290534 |
DOIs | |
Publication status | Published - 29 Nov 2024 |
Bibliographical note
Publisher Copyright:© 2025 Elsevier Inc. All rights reserved.
Keywords
- Exosome
- Gene delivery
- Gene therapy
- Vaccination
- Vaccine
ASJC Scopus subject areas
- General Medicine
- General Pharmacology, Toxicology and Pharmaceutics