Expanding the applications of microneedles in dermatology

Akmal H. Sabri, Jane Ogilvie, Khuriah Abdulhamid, Volha Shpadaruk, John McKenna, Joel Segal, David J. Scurr, Maria Marlow

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Since the first patent for microneedles was filed in the 1970s, research on utilising microneedles as a drug delivery system has progressed significantly. In addition to the extensive research on microneedles for improving transdermal drug delivery, there is a growing interest in using these devices to manage dermatological conditions. This review aims to provide the background on microneedles, the clinical benefits, and challenges of the device along with the potential dermatological conditions that may benefit from the application of such a drug delivery system. The first part of the review provides an outline on benefits and challenges of translating microneedle-based drug delivery systems into clinical practice. The second part of the review covers the application of microneedles in treating dermatological conditions. The efficacy of microneedles along with the limitations of such a strategy to treat diseased skin shall be addressed.
Original languageEnglish
Pages (from-to)121-140
Number of pages20
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume140
Early online date03 May 2019
DOIs
Publication statusPublished - 01 Jul 2019
Externally publishedYes

Keywords

  • Dermatitis
  • Dermatology
  • Microneedles
  • Psoriasis
  • Skin cancers
  • Skin infection
  • Viral warts

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