Expedient synthesis of (+)-trans-5-allylhexahydroindolizidin-3-one

D. Potts, Paul Stevenson, N. Thompson

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Treatment of the bicyclic iminium ion derived from 5-methoxyhexahydroindolizidin-3-one with allyltrimethylsilane gave exclusively the diastereoisomer in which the allyl group was axial. This substrate is a useful precursor to 5-propyl-3-alkylindolizidine alkaloids. (C) 1999 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)275-278
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number2
Publication statusPublished - 08 Apr 2000

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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