Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication

G. M. Allan*, F. McNeilly, J. Ellis, S. Krakowka, B. Meehan, I. McNair, I. Walker, S. Kennedy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

239 Citations (Scopus)

Abstract

Experimental infection of colostrum-deprived (CD) pigs with a combined inoculum of porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiated the replication and distribution of PCV2 virus, when compared with pigs inoculated with PCV2 alone. The replication and distribution of PRRSV in dually infected pigs was not enhanced, when compared to pigs inoculated with PRRSV alone. The mechanisms involved in the potentiation of PCV2 replication in PCV2/PRRSV and PCV2/porcine parvovirus (PPV) dually infected pigs may relate to the fact that monocyte/macrophage cell types are common targets of these 3 viruses.

Original languageEnglish
Pages (from-to)2421-2429
Number of pages9
JournalArchives of Virology
Volume145
Issue number11
DOIs
Publication statusPublished - 2000
Externally publishedYes

Bibliographical note

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Virology

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