Exploiting the use of ionic liquids to access phosphorodiamidites

K. Crossey, C. Hardacre, M.E. Migaud, S.E. Norman

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A series of phosphorodiamidite reagents have been readily prepared using bis{(trifluoromethyl)sulfonyl}imide based ionic liquids and compared with their syntheses in conventional organic solvents. This method demonstrates a versatile procedure that allows access to both known and novel phosphorodiamidite reagents, whilst addressing issues such as moisture sensitivity and product selectivity present in current molecular based protocols. This method negates the need for reagent purification, whilst allowing for the reactions to be conducted at high concentrations.
Original languageEnglish
Pages (from-to)2988-2993
Number of pages6
JournalRSC Advances
Issue number7
Publication statusPublished - 07 Apr 2012


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