Expression and clinical significance of nitric oxide synthase in hepatic cellular carcinoma

Hai-gang Li, Qiaozhu Su, Shu-kun Dong

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: To investigate the expression of nitric oxide synthase (NOS) and its clinical significance in hepatic cellular carcinoma (HCC). METHODS: The NOS1, NOS2 and NOS3 of 51 cases of HCC and 46 cases of liver tissue beside carcinoma (LTBC) were detected by immunohistochemistry. RESULTS: The expressive rates of NOS1, NOS2 and NOS3 in LTBC were significantly higher than those in HCC (P< 0.01). The expressive rates of NOS1 in the recurrent group were significantly higher than that in the non-recurrent group (P< 0.01). The expressive rate of NOS2 in the group without carcinoma embolus was significantly higher than that in the group with carcinoma embolus (P< 0 05). The expressive rate of NOS3 in the recurrent group was significantly higher than that in the non-recurrent group (P< 0.01). CONCLUSION: The expression of NOS1, NOS2 and NOS3 are closely related with the biological behaviours of HCC.
Original languageChinese
Pages (from-to)16-20
Number of pages5
JournalChinese Journal of Pathophysiology
Volume12
Publication statusPublished - 2001

Cite this