Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection

D. V. Ignatov, O. Yu Timoshina, N. N. Logunova, T. A. Skvortsov, T. L. Azhikina*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The determination of the mechanisms contributing to the survival of pathogenic bacteria in the infected organism and the possible ways of their blocking is a promising approach to the development of new methods of affecting these bacteria. Among these mechanisms, the regulation of bacterial metabolism by small RNAs attracts particular interest since it has been found recently to play an important role in the bacterial pathogenesis. We have studied the expression of three most highly expressed small RNAs of Mycobacterium tuberculosis: MTS0997, MTS1338, and MTS2823 during tuberculosis progression in the strains of mice having different genetic resistance to the disease. It has been shown that the maximum expression of these small RNAs occurs at earlier stages of infection. 

Original languageEnglish
Pages (from-to)233-235
Number of pages3
JournalRussian Journal of Bioorganic Chemistry
Volume40
Issue number2
DOIs
Publication statusPublished - Mar 2014

Keywords

  • expression in vivo
  • Mycobacterium tuberculosis
  • small RNAs

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry

Fingerprint Dive into the research topics of 'Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection'. Together they form a unique fingerprint.

Cite this