Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection

D. V.  Ignatov; O. Yu Timoshina; N. N. Logunova; T. A. Skvortsov; T. L. Azhikina

doi:10.1134/S1068162014020058

Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection

D. V. Ignatov, O. Yu Timoshina, N. N. Logunova, T. A. Skvortsov, T. L. Azhikina^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The determination of the mechanisms contributing to the survival of pathogenic bacteria in the infected organism and the possible ways of their blocking is a promising approach to the development of new methods of affecting these bacteria. Among these mechanisms, the regulation of bacterial metabolism by small RNAs attracts particular interest since it has been found recently to play an important role in the bacterial pathogenesis. We have studied the expression of three most highly expressed small RNAs of Mycobacterium tuberculosis: MTS0997, MTS1338, and MTS2823 during tuberculosis progression in the strains of mice having different genetic resistance to the disease. It has been shown that the maximum expression of these small RNAs occurs at earlier stages of infection.

Original language	English
Pages (from-to)	233-235
Number of pages	3
Journal	Russian Journal of Bioorganic Chemistry
Volume	40
Issue number	2
DOIs	https://doi.org/10.1134/S1068162014020058
Publication status	Published - Mar 2014

Keywords

expression in vivo
Mycobacterium tuberculosis
small RNAs

ASJC Scopus subject areas

Organic Chemistry
Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection",

abstract = "The determination of the mechanisms contributing to the survival of pathogenic bacteria in the infected organism and the possible ways of their blocking is a promising approach to the development of new methods of affecting these bacteria. Among these mechanisms, the regulation of bacterial metabolism by small RNAs attracts particular interest since it has been found recently to play an important role in the bacterial pathogenesis. We have studied the expression of three most highly expressed small RNAs of Mycobacterium tuberculosis: MTS0997, MTS1338, and MTS2823 during tuberculosis progression in the strains of mice having different genetic resistance to the disease. It has been shown that the maximum expression of these small RNAs occurs at earlier stages of infection. ",

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T1 - Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection

AU - Ignatov, D. V.

AU - Timoshina, O. Yu

AU - Logunova, N. N.

AU - Skvortsov, T. A.

AU - Azhikina, T. L.

PY - 2014/3

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N2 - The determination of the mechanisms contributing to the survival of pathogenic bacteria in the infected organism and the possible ways of their blocking is a promising approach to the development of new methods of affecting these bacteria. Among these mechanisms, the regulation of bacterial metabolism by small RNAs attracts particular interest since it has been found recently to play an important role in the bacterial pathogenesis. We have studied the expression of three most highly expressed small RNAs of Mycobacterium tuberculosis: MTS0997, MTS1338, and MTS2823 during tuberculosis progression in the strains of mice having different genetic resistance to the disease. It has been shown that the maximum expression of these small RNAs occurs at earlier stages of infection.

AB - The determination of the mechanisms contributing to the survival of pathogenic bacteria in the infected organism and the possible ways of their blocking is a promising approach to the development of new methods of affecting these bacteria. Among these mechanisms, the regulation of bacterial metabolism by small RNAs attracts particular interest since it has been found recently to play an important role in the bacterial pathogenesis. We have studied the expression of three most highly expressed small RNAs of Mycobacterium tuberculosis: MTS0997, MTS1338, and MTS2823 during tuberculosis progression in the strains of mice having different genetic resistance to the disease. It has been shown that the maximum expression of these small RNAs occurs at earlier stages of infection.

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Expression of Small RNAs of Mycobacterium tuberculosis in Murine Models of Tuberculosis Infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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