Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer

M Krockenberger, J B Engel, M Schmidt, N Kohrenhagen, S F M Häusler, Y Dombrowski, M Kapp, J Dietl, A Honig

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Malignant tumors metabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis). The metabolic switch from oxidative glycolysis to non-oxidative fermentation of glucose and proteins performed by the tumor cells seems to be associated with TKTL1 and pAkt overexpression. Therefore the aim of the present study was to investigate the expression of TKTL1 and pAkt in human specimens of endometrial cancer as compared to benign endometrium. Additionally, expression of the glucose transporter GLUT1 was also investigated as aerobic glycolysis is associated with an increased need for glucose.
Original languageEnglish
Pages (from-to)1653-9
Number of pages7
JournalAnticancer Research
Volume30
Issue number5
Publication statusPublished - May 2010

Keywords

  • Aged
  • Cell Line, Tumor
  • Endometrial Neoplasms
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Glucose
  • Glucose Transporter Type 1
  • Glycolysis
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Oxygen
  • RNA, Messenger
  • Transketolase

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