Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer

M Krockenberger; J B Engel; M Schmidt; N Kohrenhagen; S F M Häusler; Y Dombrowski; M Kapp; J Dietl; A Honig

Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer

M Krockenberger, J B Engel, M Schmidt, N Kohrenhagen, S F M Häusler, Y Dombrowski, M Kapp, J Dietl, A Honig

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Malignant tumors metabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis). The metabolic switch from oxidative glycolysis to non-oxidative fermentation of glucose and proteins performed by the tumor cells seems to be associated with TKTL1 and pAkt overexpression. Therefore the aim of the present study was to investigate the expression of TKTL1 and pAkt in human specimens of endometrial cancer as compared to benign endometrium. Additionally, expression of the glucose transporter GLUT1 was also investigated as aerobic glycolysis is associated with an increased need for glucose.

Original language	English
Pages (from-to)	1653-9
Number of pages	7
Journal	Anticancer Research
Volume	30
Issue number	5
Publication status	Published - May 2010

Keywords

Aged
Cell Line, Tumor
Endometrial Neoplasms
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Glucose
Glucose Transporter Type 1
Glycolysis
Humans
Immunohistochemistry
Middle Aged
Oxygen
RNA, Messenger
Transketolase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer",

abstract = "Malignant tumors metabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis). The metabolic switch from oxidative glycolysis to non-oxidative fermentation of glucose and proteins performed by the tumor cells seems to be associated with TKTL1 and pAkt overexpression. Therefore the aim of the present study was to investigate the expression of TKTL1 and pAkt in human specimens of endometrial cancer as compared to benign endometrium. Additionally, expression of the glucose transporter GLUT1 was also investigated as aerobic glycolysis is associated with an increased need for glucose.",

keywords = "Aged, Cell Line, Tumor, Endometrial Neoplasms, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Glucose, Glucose Transporter Type 1, Glycolysis, Humans, Immunohistochemistry, Middle Aged, Oxygen, RNA, Messenger, Transketolase",

author = "M Krockenberger and Engel, {J B} and M Schmidt and N Kohrenhagen and H{\"a}usler, {S F M} and Y Dombrowski and M Kapp and J Dietl and A Honig",

year = "2010",

month = may,

language = "English",

volume = "30",

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journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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TY - JOUR

T1 - Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer

AU - Krockenberger, M

AU - Engel, J B

AU - Schmidt, M

AU - Kohrenhagen, N

AU - Häusler, S F M

AU - Dombrowski, Y

AU - Kapp, M

AU - Dietl, J

AU - Honig, A

PY - 2010/5

Y1 - 2010/5

N2 - Malignant tumors metabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis). The metabolic switch from oxidative glycolysis to non-oxidative fermentation of glucose and proteins performed by the tumor cells seems to be associated with TKTL1 and pAkt overexpression. Therefore the aim of the present study was to investigate the expression of TKTL1 and pAkt in human specimens of endometrial cancer as compared to benign endometrium. Additionally, expression of the glucose transporter GLUT1 was also investigated as aerobic glycolysis is associated with an increased need for glucose.

AB - Malignant tumors metabolize glucose to lactate even in the presence of oxygen (aerobic glycolysis). The metabolic switch from oxidative glycolysis to non-oxidative fermentation of glucose and proteins performed by the tumor cells seems to be associated with TKTL1 and pAkt overexpression. Therefore the aim of the present study was to investigate the expression of TKTL1 and pAkt in human specimens of endometrial cancer as compared to benign endometrium. Additionally, expression of the glucose transporter GLUT1 was also investigated as aerobic glycolysis is associated with an increased need for glucose.

KW - Aged

KW - Cell Line, Tumor

KW - Endometrial Neoplasms

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Glucose

KW - Glucose Transporter Type 1

KW - Glycolysis

KW - Humans

KW - Immunohistochemistry

KW - Middle Aged

KW - Oxygen

KW - RNA, Messenger

KW - Transketolase

M3 - Article

C2 - 20592357

SN - 0250-7005

VL - 30

SP - 1653

EP - 1659

JO - Anticancer Research

JF - Anticancer Research

IS - 5

ER -

Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer

Abstract

Keywords

UN SDGs

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