Extracellular Vesicle Biogenesis in Helminths: More than One Route to the Surface?

Eduardo de la Torre Escudero, Adam P. S. Bennett, Alexzandra Clarke, Gerard P. Brennan, Mark W. Robinson

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)
428 Downloads (Pure)

Abstract

The recent discovery that parasites release extracellular vesicles (EVs) that can transfer a range of effector molecules to host cells has made us re-think our understanding of the host–parasite interface. In this opinion article we consider how recent proteomics and transcriptomics studies, together with ultrastructural observations, suggest that more than one mechanism of EV biogenesis can occur in helminths. We propose that distinct EV subtypes have roles in immune modulation and repair of drug-induced damage, and put forward the case for targeting EV biogenesis pathways to achieve parasite control. In doing so we raise a number of outstanding research questions that must be addressed before this can happen.
Original languageEnglish
Pages (from-to)921-929
Number of pages9
JournalTrends in Parasitology
Volume32
Issue number12
Early online date05 Oct 2016
DOIs
Publication statusPublished - Dec 2016

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