Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

Chloe Wylie; Rebecca Rowan; Dessi Malinova; Lisa Crawford

doi:10.1111/febs.70093

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

Chloe Wylie
, Rebecca Rowan
, Dessi Malinova^*
, Lisa Crawford^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

32 Downloads (Pure)

Abstract

Multiple myeloma (MM), characterised by the clonal proliferation of plasma cells in the bone marrow, is the second most common haematological malignancy worldwide. Although there is now an impressive artillery of therapeutics to tackle this condition, resistance remains a prevalent issue. The bone marrow microenvironment performs a crucial role in supporting MM pathogenesis and promoting the development of therapeutic resistance. Extracellular vesicles (EVs), small vesicles that carry bioactive molecules, are a key component of cell-to-cell communication within the bone marrow microenvironment. In this review, we summarise the contribution of EVs to disease progression and anticancer treatment resistance and discuss the potential therapeutic applications of EVs in MM.

Original language	English
Pages (from-to)	4979-4991
Number of pages	13
Journal	The FEBS Journal
Volume	292
Issue number	19
Early online date	09 Apr 2025
DOIs	https://doi.org/10.1111/febs.70093
Publication status	Published - Oct 2025

Keywords

extracellular vesicles
multiple myeloma
pathogenesis

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10.1111/febs.70093Licence: CC BY

Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application
Copyright 2025 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 911 KBLicence: CC BY

Cite this

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abstract = "Multiple myeloma (MM), characterised by the clonal proliferation of plasma cells in the bone marrow, is the second most common haematological malignancy worldwide. Although there is now an impressive artillery of therapeutics to tackle this condition, resistance remains a prevalent issue. The bone marrow microenvironment performs a crucial role in supporting MM pathogenesis and promoting the development of therapeutic resistance. Extracellular vesicles (EVs), small vesicles that carry bioactive molecules, are a key component of cell-to-cell communication within the bone marrow microenvironment. In this review, we summarise the contribution of EVs to disease progression and anticancer treatment resistance and discuss the potential therapeutic applications of EVs in MM. ",

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AB - Multiple myeloma (MM), characterised by the clonal proliferation of plasma cells in the bone marrow, is the second most common haematological malignancy worldwide. Although there is now an impressive artillery of therapeutics to tackle this condition, resistance remains a prevalent issue. The bone marrow microenvironment performs a crucial role in supporting MM pathogenesis and promoting the development of therapeutic resistance. Extracellular vesicles (EVs), small vesicles that carry bioactive molecules, are a key component of cell-to-cell communication within the bone marrow microenvironment. In this review, we summarise the contribution of EVs to disease progression and anticancer treatment resistance and discuss the potential therapeutic applications of EVs in MM.

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KW - pathogenesis

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Extracellular vesicles in multiple myeloma: pathogenesis and therapeutic application

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Keywords

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