Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future

International ECMO Network (ECMONet)

Research output: Contribution to journalReview article

12 Citations (Scopus)
160 Downloads (Pure)

Abstract

As a result of technical improvements, extracorporeal carbon dioxide removal (ECCO2R) now has the potential to play an important role in the management of adults with acute respiratory failure. There is growing interest in the use of ECCO2R for the management of both hypoxaemic and hypercapnic respiratory failure. However, evidence to support its use is scarce and several questions remain about the best way to implement this therapy, which can be associated with serious side-effects. This Review reflects the consensus opinion of an international group of clinician scientists with expertise in managing acute respiratory failure and in using ECCO2R therapies in this setting. We concisely review clinically relevant aspects of ECCO2R, and provide a series of recommendations for clinical practice and future research, covering topics that include the practicalities of ECCO2R delivery, indications for use, and service delivery.

Original languageEnglish
Pages (from-to)874-884
Number of pages11
JournalThe Lancet Respiratory Medicine
Volume6
Issue number11
Early online date26 Oct 2018
DOIs
Publication statusPublished - Nov 2018

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Artificial Respiration
Carbon Dioxide
Respiratory Insufficiency
Research
Therapeutics

Bibliographical note

Copyright © 2018 Elsevier Ltd. All rights reserved.

Cite this

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title = "Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future",
abstract = "As a result of technical improvements, extracorporeal carbon dioxide removal (ECCO2R) now has the potential to play an important role in the management of adults with acute respiratory failure. There is growing interest in the use of ECCO2R for the management of both hypoxaemic and hypercapnic respiratory failure. However, evidence to support its use is scarce and several questions remain about the best way to implement this therapy, which can be associated with serious side-effects. This Review reflects the consensus opinion of an international group of clinician scientists with expertise in managing acute respiratory failure and in using ECCO2R therapies in this setting. We concisely review clinically relevant aspects of ECCO2R, and provide a series of recommendations for clinical practice and future research, covering topics that include the practicalities of ECCO2R delivery, indications for use, and service delivery.",
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Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. / International ECMO Network (ECMONet).

In: The Lancet Respiratory Medicine, Vol. 6, No. 11, 11.2018, p. 874-884.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future

AU - International ECMO Network (ECMONet)

AU - Boyle, Andrew J

AU - Sklar, Michael C

AU - McNamee, James J

AU - Brodie, Daniel

AU - Slutsky, Arthur S

AU - Brochard, Laurent

AU - McAuley, Daniel F

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/11

Y1 - 2018/11

N2 - As a result of technical improvements, extracorporeal carbon dioxide removal (ECCO2R) now has the potential to play an important role in the management of adults with acute respiratory failure. There is growing interest in the use of ECCO2R for the management of both hypoxaemic and hypercapnic respiratory failure. However, evidence to support its use is scarce and several questions remain about the best way to implement this therapy, which can be associated with serious side-effects. This Review reflects the consensus opinion of an international group of clinician scientists with expertise in managing acute respiratory failure and in using ECCO2R therapies in this setting. We concisely review clinically relevant aspects of ECCO2R, and provide a series of recommendations for clinical practice and future research, covering topics that include the practicalities of ECCO2R delivery, indications for use, and service delivery.

AB - As a result of technical improvements, extracorporeal carbon dioxide removal (ECCO2R) now has the potential to play an important role in the management of adults with acute respiratory failure. There is growing interest in the use of ECCO2R for the management of both hypoxaemic and hypercapnic respiratory failure. However, evidence to support its use is scarce and several questions remain about the best way to implement this therapy, which can be associated with serious side-effects. This Review reflects the consensus opinion of an international group of clinician scientists with expertise in managing acute respiratory failure and in using ECCO2R therapies in this setting. We concisely review clinically relevant aspects of ECCO2R, and provide a series of recommendations for clinical practice and future research, covering topics that include the practicalities of ECCO2R delivery, indications for use, and service delivery.

U2 - 10.1016/S2213-2600(18)30326-6

DO - 10.1016/S2213-2600(18)30326-6

M3 - Review article

C2 - 30484429

VL - 6

SP - 874

EP - 884

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

SN - 2213-2600

IS - 11

ER -