Facile biocatalytic reduction of the carbon-carbon double bond of 5-benzylidenethiazolidine-2,4-diones. Synthesis of ( )-5-(4-{2-[methyl(2-pyridyl)amino]ethoxy}benzyl)thiazolidine-2,4-dione (BRL 49653), its (R)-(+)-enantiomer and analogs.

B.C.C. Cantello, D.S. Eggleston, David Haigh, R.C. Haltiwanger, C.M. Heath, R.M. Hindley, K.R. Jennings, J.T. Sime, S.R. Woroniecki

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