Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study

J. V. Woodside; I. S. Young; S. E.C.M. Gilchrist; J. Vioque; U. Chakravarthy; P. T.V.M. De Jong; M. Rahu; J. Seland; G. Soubrane; L. Tomazzoli; F. Topouzis; J. R. Vingerling; A. E. Fletcher

doi:10.1007/s00394-012-0456-8

Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study

J. V. Woodside^*, I. S. Young, S. E.C.M. Gilchrist, J. Vioque, U. Chakravarthy, P. T.V.M. De Jong, M. Rahu, J. Seland, G. Soubrane, L. Tomazzoli, F. Topouzis, J. R. Vingerling, A. E. Fletcher

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Purpose: To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers. Methods: Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis. Results: Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin. Conclusions: In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.

Original language	English
Pages (from-to)	1493-1501
Number of pages	9
Journal	European Journal of Nutrition
Volume	52
Issue number	5
DOIs	https://doi.org/10.1007/s00394-012-0456-8
Publication status	Published - 25 Oct 2013

Bibliographical note

Funding Information:
Acknowledgments The European Eye study was supported by the European Commission Vth Framework (QLK6-CT-1999–02094), Brussels, Belgium. Additional funding for cameras was provided by the Macular Disease Society UK, Andover, UK. Dr. Rahu was financed by the Estonian Ministry of Education and Science (target funding 01921112s02 and SF0940026s07), Tartu, Estonia. Additional funding in Alicante was received from the Spanish Ministry of Health (grant nos.: FIS 01/1692E and RCESP C 03/09), Madrid, Spain, CI-BER de Epidemiologiá y Salud Pública, and the Generalitat Valen-ciana (grant nos.: CTGCA/2002/06 and G03/136), Valencia, Spain. The sponsors or funding organisations had no role in study design, data collection, data analysis, data interpretation, writing of the paper or decision to submit the paper for publication.

Keywords

Antioxidant vitamin
Carotenoids
Confounding factors
Lifestyle factors
Older people

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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Woodside, J. V., Young, I. S., Gilchrist, S. E. C. M., Vioque, J., Chakravarthy, U., De Jong, P. T. V. M., Rahu, M., Seland, J., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J. R., & Fletcher, A. E. (2013). Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study. European Journal of Nutrition, 52(5), 1493-1501. https://doi.org/10.1007/s00394-012-0456-8

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title = "Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study",

abstract = "Purpose: To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers. Methods: Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis. Results: Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin. Conclusions: In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.",

keywords = "Antioxidant vitamin, Carotenoids, Confounding factors, Lifestyle factors, Older people",

author = "Woodside, {J. V.} and Young, {I. S.} and Gilchrist, {S. E.C.M.} and J. Vioque and U. Chakravarthy and {De Jong}, {P. T.V.M.} and M. Rahu and J. Seland and G. Soubrane and L. Tomazzoli and F. Topouzis and Vingerling, {J. R.} and Fletcher, {A. E.}",

note = "Funding Information: Acknowledgments The European Eye study was supported by the European Commission Vth Framework (QLK6-CT-1999–02094), Brussels, Belgium. Additional funding for cameras was provided by the Macular Disease Society UK, Andover, UK. Dr. Rahu was financed by the Estonian Ministry of Education and Science (target funding 01921112s02 and SF0940026s07), Tartu, Estonia. Additional funding in Alicante was received from the Spanish Ministry of Health (grant nos.: FIS 01/1692E and RCESP C 03/09), Madrid, Spain, CI-BER de Epidemiologi{\'a} y Salud P{\'u}blica, and the Generalitat Valen-ciana (grant nos.: CTGCA/2002/06 and G03/136), Valencia, Spain. The sponsors or funding organisations had no role in study design, data collection, data analysis, data interpretation, writing of the paper or decision to submit the paper for publication.",

year = "2013",

month = oct,

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doi = "10.1007/s00394-012-0456-8",

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Woodside, JV , Young, IS , Gilchrist, SECM, Vioque, J, Chakravarthy, U, De Jong, PTVM, Rahu, M, Seland, J, Soubrane, G, Tomazzoli, L, Topouzis, F, Vingerling, JR & Fletcher, AE 2013, 'Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study', European Journal of Nutrition, vol. 52, no. 5, pp. 1493-1501. https://doi.org/10.1007/s00394-012-0456-8

TY - JOUR

T1 - Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study

AU - Woodside, J. V.

AU - Young, I. S.

AU - Gilchrist, S. E.C.M.

AU - Vioque, J.

AU - Chakravarthy, U.

AU - De Jong, P. T.V.M.

AU - Rahu, M.

AU - Seland, J.

AU - Soubrane, G.

AU - Tomazzoli, L.

AU - Topouzis, F.

AU - Vingerling, J. R.

AU - Fletcher, A. E.

N1 - Funding Information: Acknowledgments The European Eye study was supported by the European Commission Vth Framework (QLK6-CT-1999–02094), Brussels, Belgium. Additional funding for cameras was provided by the Macular Disease Society UK, Andover, UK. Dr. Rahu was financed by the Estonian Ministry of Education and Science (target funding 01921112s02 and SF0940026s07), Tartu, Estonia. Additional funding in Alicante was received from the Spanish Ministry of Health (grant nos.: FIS 01/1692E and RCESP C 03/09), Madrid, Spain, CI-BER de Epidemiologiá y Salud Pública, and the Generalitat Valen-ciana (grant nos.: CTGCA/2002/06 and G03/136), Valencia, Spain. The sponsors or funding organisations had no role in study design, data collection, data analysis, data interpretation, writing of the paper or decision to submit the paper for publication.

PY - 2013/10/25

Y1 - 2013/10/25

N2 - Purpose: To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers. Methods: Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis. Results: Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin. Conclusions: In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.

AB - Purpose: To report on plasma/serum levels of antioxidant vitamin and carotenoids in older adults resident in multiple countries in Europe and examine relationships with potential modifiers. Methods: Population-based cross-sectional European Eye Study in 7 centres from northern to southern Europe. In total, 4,133 participants aged 65 years or over, collected by random sampling, were recruited. Questionnaires relating to diet, lifestyle and medical history were administered. Non-fasting blood samples were analysed in a single laboratory for vitamins A, C and E and a panel of carotenoids. Associations were analysed by bootstrapped multivariable regression analysis. Results: Centre and season influenced the serum and plasma concentrations of all antioxidant vitamins and carotenoids. Gender, BMI, smoking, age, education, alcohol consumption and supplement use were also significantly associated with some, but not all, of the antioxidant vitamins and carotenoids examined. The proportion of variance explained ranged from 4.8 % for retinol to 25.2 % for zeaxanthin. Conclusions: In older people, antioxidant vitamin and carotenoid status varies by centre and season, but is also associated with other behavioural and lifestyle variables. Studies aiming to demonstrate an association between antioxidant vitamins and carotenoid status and chronic disease risk should consider these potential confounders.

KW - Antioxidant vitamin

KW - Carotenoids

KW - Confounding factors

KW - Lifestyle factors

KW - Older people

U2 - 10.1007/s00394-012-0456-8

DO - 10.1007/s00394-012-0456-8

M3 - Article

C2 - 23097178

AN - SCOPUS:84880828105

SN - 1436-6207

VL - 52

SP - 1493

EP - 1501

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 5

ER -

Factors associated with serum/plasma concentrations of vitamins A, C, e and carotenoids in older people throughout Europe: The EUREYE study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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