Family-based association studies of lipid gene polymorphisms in coronary artery disease

C Belton, P Horan, Paul McGlinchey, M Spence, D Fogarty, Adrian Allen, Chris Patterson, Alun Evans, Pascal McKeown

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11 Citations (Scopus)

Abstract

Dysfunction of lipid-metabolizing proteins is implicated in the pathogenesis of coronary artery disease. Single nucleotide polymorphisms in genes that encode sterol regulatory binding protein-la, adenosine triphosphate binding cassette-A1, hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein were assessed as potential markers of disease susceptibility in a family-based study of 1,012 patients from 386 families. Association between single nucleotide polymorphisms and coronary artery disease was tested by the combined transmission disequilibrium test/sib transmission disequilibrium test and pedigree disequilibrium test. After Bonferroni's correction, the pedigree disequilibrium test demonstrated significant excess transmission (p < 0.0083) to affected patients of the hepatic lipase -514 T allele, which suggests that this may constitute a novel disease-susceptibility locus. (c) 2005 Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalAmerican Journal of Cardiology
Volume96
Issue number1
Publication statusPublished - 01 Jul 2005

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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