Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation

I. Singh, Joseph Vyle, F. Heaney

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Solid-phase oligonucleotide conjugation by nitrile oxide-alkyne click cycloaddition chemistry has been successfully demonstrated; the reaction, compatible with all nucleobases, requires no metal catalyst and proceeds under physiological conditions.
Original languageEnglish
Pages (from-to)3276-3278
Number of pages3
JournalChemical Communications
Volume22
Issue number22
Early online date22 Apr 2009
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Metals and Alloys
  • Surfaces, Coatings and Films

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