FAST Hydrogenations as a Continuous Platform for Green Aromatic Nitroreductions

Haresh Manyar*, Md Taifur Rahman, Scott Wharry, Megan Smyth, Thomas Moody

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

A continuous-flow packed-bed catalytic reactor has been developed for hydrogenation of aromatic nitrobenzoic acids in water to the corresponding anilines. These reductions are green, more efficient, less consumptive and safer reductive processes. Various industrially important aromatic amines have been produced in excellent yields and with high throughput. The optimized continuous flow reduction process produced no detectable Genotoxic Impurity (GTI) intermediates as compared with the corresponding batch mediated reduction. The reactor is modular in design and can be scaled-up for multi-kg/day product delivery without extensive re-design.
Original languageEnglish
JournalSynlett
Publication statusAccepted - 28 Jan 2020

    Fingerprint

Cite this

Manyar, H., Rahman, M. T., Wharry, S., Smyth, M., & Moody, T. (Accepted/In press). FAST Hydrogenations as a Continuous Platform for Green Aromatic Nitroreductions. Synlett.