Fast, quantitative nucleoside protection under solvent-free conditions

Nicola Giri, Caroline Bowen, Joseph Vyle, Stuart James

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Persilylation of nucleoside hydroxyls was effected in quantitative yields under solvent-free conditions using a ball mill. In addition, one-pot persilylation and acylation of cytidine was performed as an exemplar reaction demonstrating the utility of solvent-free approaches to nucleoside chemistry.
Original languageEnglish
Pages (from-to)627-628
Number of pages2
JournalGreen Chemistry
Volume10
Issue number6
Early online date30 Apr 2008
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Chemistry(all)

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