Fate of inflammatory neutrophils within the joint

Aubrey Bell, Alexandra Irvine, K. Magill, R. Mc Kane

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


OBJECTIVE: Impaired flow-mediated dilation (FMD) occurs in disease states associated with atherosclerosis, including SLE. The primary hemodynamic determinant of FMD is wall shear stress, which is critically dependent on the forearm microcirculation. We explored the relationship between FMD, diastolic shear stress (DSS), and the forearm microcirculation in 32 patients with SLE and 19 controls. METHODS AND RESULTS: DSS was calculated using (mean diastolic velocity x 8 x blood viscosity)/baseline brachial artery diameter. Doppler velocity envelopes from the first 15 seconds of reactive hyperemia were analyzed for resistive index (RI), and interrogated in the frequency domain to assess forearm microvascular hemodynamics. FMD was significantly impaired in SLE patients (median, 2.4%; range, -2.1% to 10.7% versus median 5.8%; range, 1.9% to 14%; P
Original languageEnglish
Pages (from-to)1274-1275
Number of pages2
Issue number10
Publication statusPublished - 01 Oct 2003

ASJC Scopus subject areas

  • Rheumatology
  • Neuroscience(all)


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