Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series

Malcolm Brown*, Dominic O'Connor, Richard Turkington, Martin Eatock, Rebecca Vince, Claire Hulme, Roy Bowdery, Rebecca Robinson, Jonathan Wadsley, Anthony Maraveyas, Gillian Prue

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Downloads (Pure)

Abstract

Introduction
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive neoplasm, with surgical resection and adjuvant chemotherapy the only curative treatment. Treatment-related toxicities place a considerable burden on patients although exercise training has shown promise is helping to manage such adversities and facilitate rehabilitation. The feasibility and safety of exercise training as a supportive therapy during adjuvant chemotherapy remains unknown.

Methods
Patients with PDAC were screened post-surgical resection and enrolled in a 16-week, progressive, concurrent exercise programme alongside their chemotherapy regimen. Feasibility was the primary objective detailing recruitment, retention and adherence rates throughout as well as the safety and fidelity of the intervention. Secondarily, the impact on functional fitness and patient-reported outcomes was captured at baseline, post-intervention and 3-month follow up.

Results
Eight patients consented to participate in this trial, with five proceeding to enrol in exercise training. Concurrent exercise training is feasible and safe during adjuvant chemotherapy and prevented an expected decline in functional fitness and patient-reported outcomes during this time.

Discussion
This case series provides preliminary evidence that concurrent exercise training during adjuvant therapy is safe, feasible and well tolerated, preventing an expected decline in functional fitness, muscular strength and health-related quality of life (HRQoL). Given the adverse effects of treatment, these findings are promising and provide further evidence for the inclusion of exercise training as a standard of care for surgical rehabilitation and managing treatment-related toxicities. Future research should explore the impact of exercise training during neoadjuvant chemotherapy, with prehabilitation now standard practice for borderline resectable disease.

Trial registrationClinicalTrials.gov Identifier: NCT04305067, prospectively registered 12/03/2020, https://classic.clinicaltrials.gov/ct2/show/NCT04305067.

Original languageEnglish
Article number116
Number of pages13
JournalBMC Sports Science, Medicine and Rehabilitation
Volume15
DOIs
Publication statusPublished - 21 Sept 2023

Keywords

  • Exercise
  • Feasibility
  • Functional Fitness
  • Pancreatic Ductal Adenocarcinoma
  • Patient-reported Outcomes

Fingerprint

Dive into the research topics of 'Feasibility of delivering supervised exercise training following surgical resection and during adjuvant chemotherapy for pancreatic ductal adenocarcinoma (PRECISE): a case series'. Together they form a unique fingerprint.

Cite this