Feeding association between the nucleus of the solitary tract and the ventral tegmental area

E.M. Kim, Joseph Quinn, D. Spanswick, Eugene O'Hare

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Male Sprague-Dawley rats were fitted with two cannulae in the VTA and one cannula in the NTS for co-administration of the mu-opioid receptoragonist DAMGO in one site and the opioid antagonist naltrexone in the other. Injection of DAMGO into the VTA or the NTS stimulated feeding. The increase in food intake after DAMGO injection into the VTA was decreased following injection of naltrexone into the NTS. Furthermore, the increase in food intake after DAMGO injection into the NTS was decreased following injection of naltrexone into the VTA. These results suggest an opioid-mediated feeding association between the VTA and NTS. (C) 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)457-460
Number of pages4
JournalAppetite
Volume53
Issue number3
DOIs
Publication statusPublished - Dec 2009

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