Abstract
A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.
Original language | English |
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Pages (from-to) | 204-8 |
Number of pages | 5 |
Journal | Clinical Rheumatology |
Volume | 14 |
Issue number | 2 |
Publication status | Published - Mar 1995 |
Keywords
- Arthritis, Rheumatoid
- Drug Eruptions
- Felty Syndrome
- Granulocyte Colony-Stimulating Factor
- Humans
- Male
- Middle Aged
- Neutropenia
- Recombinant Proteins