Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

M F McMullin; M B Finch

Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

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Abstract

A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

Original language	English
Pages (from-to)	204-8
Number of pages	5
Journal	Clinical Rheumatology
Volume	14
Issue number	2
Publication status	Published - Mar 1995

Keywords

Arthritis, Rheumatoid
Drug Eruptions
Felty Syndrome
Granulocyte Colony-Stimulating Factor
Humans
Male
Middle Aged
Neutropenia
Recombinant Proteins

Cite this

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title = "Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash",

abstract = "A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.",

keywords = "Arthritis, Rheumatoid, Drug Eruptions, Felty Syndrome, Granulocyte Colony-Stimulating Factor, Humans, Male, Middle Aged, Neutropenia, Recombinant Proteins",

author = "McMullin, {M F} and Finch, {M B}",

year = "1995",

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AU - Finch, M B

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N2 - A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

AB - A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.

KW - Arthritis, Rheumatoid

KW - Drug Eruptions

KW - Felty Syndrome

KW - Granulocyte Colony-Stimulating Factor

KW - Humans

KW - Male

KW - Middle Aged

KW - Neutropenia

KW - Recombinant Proteins

M3 - Article

C2 - 7540527

SN - 0770-3198

VL - 14

SP - 204

EP - 208

JO - Clinical Rheumatology

JF - Clinical Rheumatology

IS - 2

ER -

Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

Abstract

Keywords

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