Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash

M F McMullin, M B Finch

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.
Original languageEnglish
Pages (from-to)204-8
Number of pages5
JournalClinical Rheumatology
Volume14
Issue number2
Publication statusPublished - Mar 1995

Keywords

  • Arthritis, Rheumatoid
  • Drug Eruptions
  • Felty Syndrome
  • Granulocyte Colony-Stimulating Factor
  • Humans
  • Male
  • Middle Aged
  • Neutropenia
  • Recombinant Proteins

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