Fenofibrate for Diabetic Retinopathy

Stephen Stewart, Noemi Lois

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Fenofibrate is a safe and inexpensive orally administered fibric acid derivative conventionally used to treat dyslipidemia. Two large randomized clinical trials, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and the Action to Control Cardiovascular Risk in Diabetes (ACCORD) studies, demonstrated the benefit of oral fenofibrate in the treatment of people with type 2 diabetes and diabetic retinopathy (DR), including reduced disease progression and need for laser treatment for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR). These findings are supported by results of experimental studies, which have demonstrated beneficial effects of fenofibrate ameliorating retinal vascular leakage and leukostasis, downregulating vascular endothelial growth factor (VEGF), and reducing endothelial cell and pericyte loss, among others-all characteristic features of DR. Fenofibrate is not prescribed routinely for the treatment of patients with diabetes and DR, despite this evidence. In FIELD and ACCORD, retinopathy was not the primary outcome and this may explain, at least partly, its lack of use for this indication. New trials are now underway to specifically address the effects of fenofibrate in DR; these trials will provide additional and robust data that may support current evidence favoring the use of fenofibrate in this common microvascular complication of diabetes.

Original languageEnglish
JournalAsia-Pacific Journal of Ophthalmology
Early online date30 Jul 2018
DOIs
Publication statusEarly online date - 30 Jul 2018

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