First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness

G. A.P. Cirrone*, L. Manti, D. Margarone, G. Petringa, L. Giuffrida, A. Minopoli, A. Picciotto, G. Russo, F. Cammarata, P. Pisciotta, F. M. Perozziello, F. Romano, V. Marchese, G. Milluzzo, V. Scuderi, G. Cuttone, G. Korn

*Corresponding author for this work

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Abstract

Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper 12C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + 11B → 3α reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses 10B-enriched BSH for neutron irradiation-triggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy's ballistic precision with the higher RBE promised by BNCT and 12C-ion therapy is thus demonstrated.

Original languageEnglish
Article number1261
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 18 Jan 2018
Externally publishedYes

ASJC Scopus subject areas

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    Cirrone, G. A. P., Manti, L., Margarone, D., Petringa, G., Giuffrida, L., Minopoli, A., Picciotto, A., Russo, G., Cammarata, F., Pisciotta, P., Perozziello, F. M., Romano, F., Marchese, V., Milluzzo, G., Scuderi, V., Cuttone, G., & Korn, G. (2018). First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness. Scientific Reports, 8(1), [1261]. https://doi.org/10.1038/s41598-018-19258-5