First report of klebsiella oxytoca strain simultaneously producing NDM-1, IMP-4, and KPC-2 carbapenemases

Juan Wang; Min Yuan; Hai Chen; Xia Chen; Yuanchun Jia; Xiong Zhu; Li Bai; Xue Bai; Séamus Fanning; Jinxing Lu; Juan Li

doi:10.1128/AAC.00877-17

First report of klebsiella oxytoca strain simultaneously producing NDM-1, IMP-4, and KPC-2 carbapenemases

Juan Wang, Min Yuan, Hai Chen, Xia Chen, Yuanchun Jia, Xiong Zhu, Li Bai, Xue Bai, Séamus Fanning, Jinxing Lu, Juan Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that bla_NDM-1 was carried on an IncX3 plasmid. The bla_IMP-4 and bla_KPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.

Original language	English
Article number	e00877-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
Issue number	9
Early online date	24 Aug 2017
DOIs	https://doi.org/10.1128/AAC.00877-17
Publication status	Published - Sept 2017

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (grant 81501783), the Ministry of Science and Technology (grant 2015CB554200), and the China Postdoctoral Science Foundation (grant 2017M613231). We have no conflicts of interest to declare.

Publisher Copyright:
Copyright © 2017 American Society for Microbiology. All Rights Reserved.

Keywords

Carbapenemases
KPC-2
MBLs
MDR Klebsiella oxytoca
Plasmids

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00877-17Licence: Unspecified

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title = "First report of klebsiella oxytoca strain simultaneously producing NDM-1, IMP-4, and KPC-2 carbapenemases",

abstract = "The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that blaNDM-1 was carried on an IncX3 plasmid. The blaIMP-4 and blaKPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.",

keywords = "Carbapenemases, KPC-2, MBLs, MDR Klebsiella oxytoca, Plasmids",

author = "Juan Wang and Min Yuan and Hai Chen and Xia Chen and Yuanchun Jia and Xiong Zhu and Li Bai and Xue Bai and S{\'e}amus Fanning and Jinxing Lu and Juan Li",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (grant 81501783), the Ministry of Science and Technology (grant 2015CB554200), and the China Postdoctoral Science Foundation (grant 2017M613231). We have no conflicts of interest to declare. Publisher Copyright: Copyright {\textcopyright} 2017 American Society for Microbiology. All Rights Reserved.",

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doi = "10.1128/AAC.00877-17",

language = "English",

volume = "61",

journal = "Antimicrobial Agents and Chemotherapy",

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AU - Wang, Juan

AU - Yuan, Min

AU - Chen, Hai

AU - Chen, Xia

AU - Jia, Yuanchun

AU - Zhu, Xiong

AU - Bai, Li

AU - Bai, Xue

AU - Fanning, Séamus

AU - Lu, Jinxing

AU - Li, Juan

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (grant 81501783), the Ministry of Science and Technology (grant 2015CB554200), and the China Postdoctoral Science Foundation (grant 2017M613231). We have no conflicts of interest to declare. Publisher Copyright: Copyright © 2017 American Society for Microbiology. All Rights Reserved.

PY - 2017/9

Y1 - 2017/9

N2 - The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that blaNDM-1 was carried on an IncX3 plasmid. The blaIMP-4 and blaKPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.

AB - The nucleotide sequences of five plasmids from one Klebsiella oxytoca isolate were determined using the PacBio RS II system. Plasmid analysis revealed that blaNDM-1 was carried on an IncX3 plasmid. The blaIMP-4 and blaKPC-2 genes were located on IncN and IncP-6 plasmids, respectively. Comparative sequence analysis highlighted the successful spread of carbapenemase-harboring plasmids among different enterobacterial species. We report for the first time, to our knowledge, coproducing NDM-1, KPC-2, and IMP-4 carbapenemases on a K. oxytoca isolate.

KW - Carbapenemases

KW - KPC-2

KW - MBLs

KW - MDR Klebsiella oxytoca

KW - Plasmids

U2 - 10.1128/AAC.00877-17

DO - 10.1128/AAC.00877-17

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AN - SCOPUS:85028317084

SN - 0066-4804

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

M1 - e00877-17

ER -

First report of klebsiella oxytoca strain simultaneously producing NDM-1, IMP-4, and KPC-2 carbapenemases

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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