First results on cell irradiation with laser-driven protons on the TARANIS system

S. Kar; D. Doria; K.F. Kakolee; R. Prasad; S. Litt; H. Ahmed; G. Nersisyan; C. Lewis; M. Zepf; M. Borghesi; G. Schettino; K.M. Prise; F. Fiorini; D. Kirby; S. Green; J.C.G. Jeynes; M.J. Merchant; K.J. Kirkby

doi:10.1063/1.4816612

First results on cell irradiation with laser-driven protons on the TARANIS system

S. Kar, D. Doria, K.F. Kakolee, R. Prasad, S. Litt, H. Ahmed, G. Nersisyan, C. Lewis, M. Zepf, M. Borghesi, G. Schettino, K.M. Prise, F. Fiorini, D. Kirby, S. Green, J.C.G. Jeynes, M.J. Merchant, K.J. Kirkby

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

223 Downloads (Pure)

Abstract

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

Original language	English
Title of host publication	AIP Conference Proceedings
Pages	87-89
Number of pages	3
Volume	1546
Edition	1
DOIs	https://doi.org/10.1063/1.4816612
Publication status	Published - 2013
Event	AIP Conference 2012 - Catania, Italy Duration: 18 Oct 2012 → 19 Oct 2012

Conference

Conference	AIP Conference 2012
Country	Italy
City	Catania
Period	18/10/2012 → 19/10/2012

Access to Document

10.1063/1.4816612

First Results on Cell Irradiation with laser-driven protons on the TARANIS system
© 2013 AIP Publishing LLC
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Kar, S., Doria, D., Kakolee, K. F., Prasad, R., Litt, S., Ahmed, H., Nersisyan, G., Lewis, C., Zepf, M., Borghesi, M., Schettino, G., Prise, K. M., Fiorini, F., Kirby, D., Green, S., Jeynes, J. C. G., Merchant, M. J., & Kirkby, K. J. (2013). First results on cell irradiation with laser-driven protons on the TARANIS system. In AIP Conference Proceedings (1 ed., Vol. 1546, pp. 87-89) https://doi.org/10.1063/1.4816612

Kar, S. ; Doria, D. ; Kakolee, K.F. ; Prasad, R. ; Litt, S. ; Ahmed, H. ; Nersisyan, G. ; Lewis, C. ; Zepf, M. ; Borghesi, M. ; Schettino, G. ; Prise, K.M. ; Fiorini, F. ; Kirby, D. ; Green, S. ; Jeynes, J.C.G. ; Merchant, M.J. ; Kirkby, K.J. / First results on cell irradiation with laser-driven protons on the TARANIS system. AIP Conference Proceedings. Vol. 1546 1. ed. 2013. pp. 87-89

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title = "First results on cell irradiation with laser-driven protons on the TARANIS system",

abstract = "The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. ",

author = "S. Kar and D. Doria and K.F. Kakolee and R. Prasad and S. Litt and H. Ahmed and G. Nersisyan and C. Lewis and M. Zepf and M. Borghesi and G. Schettino and K.M. Prise and F. Fiorini and D. Kirby and S. Green and J.C.G. Jeynes and M.J. Merchant and K.J. Kirkby",

year = "2013",

doi = "10.1063/1.4816612",

language = "English",

isbn = "9780735411715",

volume = "1546",

pages = "87--89",

booktitle = "AIP Conference Proceedings",

edition = "1",

note = "AIP Conference 2012 ; Conference date: 18-10-2012 Through 19-10-2012",

}

Kar, S, Doria, D, Kakolee, KF, Prasad, R, Litt, S, Ahmed, H, Nersisyan, G, Lewis, C , Zepf, M , Borghesi, M, Schettino, G, Prise, KM, Fiorini, F, Kirby, D, Green, S, Jeynes, JCG, Merchant, MJ & Kirkby, KJ 2013, First results on cell irradiation with laser-driven protons on the TARANIS system. in AIP Conference Proceedings. 1 edn, vol. 1546, pp. 87-89, AIP Conference 2012, Catania, Italy, 18/10/2012. https://doi.org/10.1063/1.4816612

First results on cell irradiation with laser-driven protons on the TARANIS system. / Kar, S.; Doria, D.; Kakolee, K.F.; Prasad, R.; Litt, S.; Ahmed, H.; Nersisyan, G.; Lewis, C.; Zepf, M.; Borghesi, M.; Schettino, G.; Prise, K.M.; Fiorini, F.; Kirby, D.; Green, S.; Jeynes, J.C.G.; Merchant, M.J.; Kirkby, K.J.

AIP Conference Proceedings. Vol. 1546 1. ed. 2013. p. 87-89.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - First results on cell irradiation with laser-driven protons on the TARANIS system

AU - Kar, S.

AU - Doria, D.

AU - Kakolee, K.F.

AU - Prasad, R.

AU - Litt, S.

AU - Ahmed, H.

AU - Nersisyan, G.

AU - Lewis, C.

AU - Zepf, M.

AU - Borghesi, M.

AU - Schettino, G.

AU - Prise, K.M.

AU - Fiorini, F.

AU - Kirby, D.

AU - Green, S.

AU - Jeynes, J.C.G.

AU - Merchant, M.J.

AU - Kirkby, K.J.

PY - 2013

Y1 - 2013

N2 - The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

AB - The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.

U2 - 10.1063/1.4816612

DO - 10.1063/1.4816612

M3 - Conference contribution

AN - SCOPUS:84881266949

SN - 9780735411715

VL - 1546

SP - 87

EP - 89

BT - AIP Conference Proceedings

T2 - AIP Conference 2012

Y2 - 18 October 2012 through 19 October 2012

ER -