First results on cell irradiation with laser-driven protons on the TARANIS system

S. Kar, D. Doria, K.F. Kakolee, R. Prasad, S. Litt, H. Ahmed, G. Nersisyan, C. Lewis, M. Zepf, M. Borghesi, G. Schettino, K.M. Prise, F. Fiorini, D. Kirby, S. Green, J.C.G. Jeynes, M.J. Merchant, K.J. Kirkby

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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239 Downloads (Pure)

Abstract

The ultra short duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 10 Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live, cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source.
Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages87-89
Number of pages3
Volume1546
Edition1
DOIs
Publication statusPublished - 2013
EventAIP Conference 2012 - Catania, Italy
Duration: 18 Oct 201219 Oct 2012

Conference

ConferenceAIP Conference 2012
CountryItaly
CityCatania
Period18/10/201219/10/2012

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    Kar, S., Doria, D., Kakolee, K. F., Prasad, R., Litt, S., Ahmed, H., Nersisyan, G., Lewis, C., Zepf, M., Borghesi, M., Schettino, G., Prise, K. M., Fiorini, F., Kirby, D., Green, S., Jeynes, J. C. G., Merchant, M. J., & Kirkby, K. J. (2013). First results on cell irradiation with laser-driven protons on the TARANIS system. In AIP Conference Proceedings (1 ed., Vol. 1546, pp. 87-89) https://doi.org/10.1063/1.4816612