Flat SAR of P3-methylsulphonamide based small molecule legumain inhibitors

Kerry Anne Ness, Sharon L Eddie, Stephanie Burton, Timothy Harrison, Paul Mullan, Rich Williams

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This letter describes the design, development and SAR exploration of a novel series of small legumain inhibitors. The SAR of a new small molecule legumain inhibitor chemotype was explored and found to have improved physiochemical properties compared to previously developed inhibitors within our group. However, further development of this series was found to be limited as the SAR was observed to be relatively flat.

Original languageEnglish
Pages (from-to)413-6
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number2
Early online date28 Nov 2015
DOIs
Publication statusPublished - 15 Jan 2016

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