FMRFamide-related peptides (FaRPs): A new family of peptides from amphibian defensive skin secretions

Lei Wang, Anita Smyth, Anders H. Johnsen, Mei Zhou, Tianbao Chen, Brian Walker, Chris Shaw

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Amphibian defensive skin secretions are known to contain a plethora of biologically-active peptides that are often structural and functional analogues of vertebrate neuropeptides. Here we report the structures of two invertebrate neuropeptide analogues, IPPQFMRF amide (IF-8 amide) and EGDEDEFLRF amide (EF-10 amide), from the defensive skin secretions of two different species of African hyperoliid frogs, Kassina maculata and Phylictimantis verrucosus, respectively. These represent the first canonical FMRF amide-related peptides (FaRPs) from a vertebrate source. The cDNA encoding IF-8 amide was cloned from a skin secretion library and found to contain a single copy of the peptide located at the C-terminus of a 58 amino acid residue open-reading frame. These data extend the potential targets of the defensive arsenal of amphibian tegumental secretions to parasitic/predatory invertebrates and the novel peptides described may represent the first vertebrate peptidic endectocides.
Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 05 Jun 2009

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology


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