Focal irradiation of perforating eye injuries

U. Chakravarthy, J. H. Biggart, T. A. Gardiner, D. B. Archer, C. J. Maguire

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Plaques constructed with 125I were used to irradiate the sites of perforating ocular injuries in rabbits. An approximate dose of 16Gy given over a period of 6 days was shown to significantly reduce intraocular cellular proliferation when irradiation was commenced within 24 hours after injury. If irradiation was delayed until day 5, this reduction in cellular proliferation and intraocular membrane formation did not occur. Smaller radiation doses of approximately 6Gy given within 24 hours post-injury and administered over 6 days also reduced the extent of cellular proliferation but was not as effective as the 16Gy dose.
Original languageEnglish
Pages (from-to)1241-1250
Number of pages10
JournalCurrent eye research
Volume8
Issue number12
Publication statusPublished - 01 Dec 1989

Bibliographical note

LR: 20061115; JID: 8104312; 0 (Iodine Radioisotopes); ppublish

Keywords

  • Animals
  • Brachytherapy
  • Cell Division/radiation effects
  • Dose-Response Relationship, Radiation
  • Eye Injuries, Penetrating/radiotherapy
  • Gamma Rays
  • Iodine Radioisotopes
  • Rabbits
  • Random Allocation
  • Retina/pathology/radiation effects
  • Sclera/pathology/radiation effects
  • Time Factors
  • Vitreous Body/pathology/radiation effects
  • Wound Healing/radiation effects

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