Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register

J.I. Morrow, S.J. Hunt, A.J. Russell, W.H. Smithson, L. Parsons, I. Robertson, R. Waddell, B. Irwin, Patrick Morrison, J.J. Craig

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)

Abstract

Objective: In the general population, folic acid supplementation during pregnancy has been demonstrated to reduce the frequency of neural tube defects (NTDs) and other major congenital malformations (MCMs). It is recommended that women with epilepsy contemplating pregnancy take supplemental folic acid because of the known antifolate effect of some antiepileptic drugs (AEDs). Here the aim was to determine the effectiveness of this practice.
Original languageEnglish
Pages (from-to)506-511
Number of pages6
JournalJOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Volume80
Issue number5
DOIs
Publication statusPublished - May 2009

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery

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