Formulation of an implantable device from mini tablets-in-PCL cylinders for sustained delivery of a hydrophobic drug

Camila Julieta Picco, Peter E. McKenna, Ryan F. Donnelly, Eneko Larrañeta*

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Implantable drug delivery systems are presented as a potential alternative to current treatments of chronic conditions. The aim of this work was to formulate a subcutaneous implantable device made with prefabricated poly(caprolactone) (PCL) cylinders, loaded with olanzapine (OLZ) as a model drug and cyclodextrin in a mass ratio of 1:1. The final formulation was characterized using optical microscopy, infrared spectroscopy, thermal analysis, and X-ray diffraction. The proposed device was successfully fabricated and demonstrated ability to control drug release for 60 days. With continued development, these novel implants could be an alternative to currently available treatments for schizophrenia.

Original languageEnglish
Article number1153
Pages (from-to)S1-S2
Number of pages2
JournalBritish Journal of Pharmacy
Volume7
Issue number2
DOIs
Publication statusPublished - 04 Nov 2022

Keywords

  • Management Science and Operations Research
  • Mechanical Engineering
  • Energy Engineering and Power Technology

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